deltatrials
Terminated PHASE2 INTERVENTIONAL 2-arm NCT03919162

A Trial to Evaluate the Efficacy and Safety of PQ912 in Patients With Early AD (VIVA-MIND)

A Phase 2A Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Varoglutamstat (PQ912) in Patients With Early Alzheimer's Disease With a Stage-Gate to Phase 2B (VIVA-MIND)

Sponsor: Alzheimer's Disease Cooperative Study (ADCS)

Interventions PQ912 Placebo
Updated 32 times since 2019 Last updated: Dec 5, 2025 Started: Nov 15, 2021 Primary completion: Jul 12, 2024 Completion: Aug 12, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

It has been made the strategic decision to terminate the study. This decision to terminate the study early is not being made for safety reasons.

A PHASE2 clinical study on Alzheimer Disease, this trial is terminated or withdrawn. The trial is conducted by Alzheimer's Disease Cooperative Study (ADCS) and has accumulated 32 data snapshots since 2021. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Dec 2019 · 6 months · monthly snapshot~Dec 2019 – ~Apr 2020 · 4 months · monthly snapshot~Apr 2020 – ~Jul 2020 · 3 months · monthly snapshot~Jul 2020 – ~Sep 2020 · 2 months · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Apr 2021 · 59 days · monthly snapshot~Apr 2021 – ~Sep 2021 · 5 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Mar 2022 · 59 days · monthly snapshot~Mar 2022 – ~Jun 2022 · 3 months · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Dec 2022 · 5 months · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~Aug 2023 · 4 months · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Nov 2023 · 2 months · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~May 2024 · 5 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Aug 2025 · 11 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Jan 2026 · 4 months · monthly snapshot~Jan 2026 – present · 5 months · monthly snapshot

Change History

32 versions recorded
  1. Jan 2026 — Present [monthly]

    Terminated PHASE2

  2. Sep 2025 — Jan 2026 [monthly]

    Terminated PHASE2

  3. Aug 2025 — Sep 2025 [monthly]

    Terminated PHASE2

  4. Sep 2024 — Aug 2025 [monthly]

    Terminated PHASE2

    Status: Active Not RecruitingTerminated

  5. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

Show 27 earlier versions
  1. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE2

  2. May 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

  3. Dec 2023 — May 2024 [monthly]

    Recruiting PHASE2

  4. Nov 2023 — Dec 2023 [monthly]

    Recruiting PHASE2

  5. Sep 2023 — Nov 2023 [monthly]

    Recruiting PHASE2

  6. Aug 2023 — Sep 2023 [monthly]

    Recruiting PHASE2

  7. Apr 2023 — Aug 2023 [monthly]

    Recruiting PHASE2

  8. Feb 2023 — Apr 2023 [monthly]

    Recruiting PHASE2

  9. Dec 2022 — Feb 2023 [monthly]

    Recruiting PHASE2

  10. Jul 2022 — Dec 2022 [monthly]

    Recruiting PHASE2

  11. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  12. Mar 2022 — Jun 2022 [monthly]

    Recruiting PHASE2

  13. Jan 2022 — Mar 2022 [monthly]

    Recruiting PHASE2

  14. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE2

  15. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  16. Oct 2021 — Nov 2021 [monthly]

    Not Yet Recruiting PHASE2

  17. Sep 2021 — Oct 2021 [monthly]

    Not Yet Recruiting PHASE2

  18. Apr 2021 — Sep 2021 [monthly]

    Not Yet Recruiting PHASE2

  19. Feb 2021 — Apr 2021 [monthly]

    Not Yet Recruiting PHASE2

  20. Jan 2021 — Feb 2021 [monthly]

    Not Yet Recruiting PHASE2

  21. Oct 2020 — Jan 2021 [monthly]

    Not Yet Recruiting PHASE2

  22. Sep 2020 — Oct 2020 [monthly]

    Not Yet Recruiting PHASE2

  23. Jul 2020 — Sep 2020 [monthly]

    Not Yet Recruiting PHASE2

  24. Apr 2020 — Jul 2020 [monthly]

    Not Yet Recruiting PHASE2

  25. Dec 2019 — Apr 2020 [monthly]

    Not Yet Recruiting PHASE2

  26. Jun 2019 — Dec 2019 [monthly]

    Not Yet Recruiting PHASE2

  27. May 2019 — Jun 2019 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Alzheimer's Disease Cooperative Study (ADCS)
  • National Institute on Aging (NIA)
  • Vivoryon Therapeutics N.V.
Data source: Vivoryon Therapeutics N.V.

For direct contact, visit the study record on ClinicalTrials.gov .