deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT03941860

Testing the Addition of Ixazomib/Placebo to Lenalidomide in Patients With Evidence of Residual Multiple Myeloma, OPTIMUM Trial

Optimizing Prolonged Treatment In Myeloma Using MRD Assessment (OPTIMUM)

Sponsor: National Cancer Institute (NCI)

Updated 57 times since 2019 Last updated: May 8, 2025 Started: Feb 16, 2022 Primary completion: Aug 6, 2023 Completion: Jan 31, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Multiple Myeloma, this trial is completed. The trial is conducted by National Cancer Institute (NCI) and has accumulated 57 data snapshots since 2022. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Nov 2019 · 2 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Sep 2020 · 2 months · monthly snapshot~Sep 2020 – ~Dec 2020 · 3 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Jun 2021 · 2 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Mar 2025 · 59 days · monthly snapshot~Mar 2025 – ~Jun 2025 · 3 months · monthly snapshot~Jun 2025 – ~Sep 2025 · 3 months · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

57 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Jun 2025 — Sep 2025 [monthly]

    Completed PHASE3

  3. Mar 2025 — Jun 2025 [monthly]

    Completed PHASE3

    Status: Active Not RecruitingCompleted

  4. Jan 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Dec 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE3

Show 52 earlier versions
  1. Nov 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE3

  2. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE3

  3. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  4. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE3

  5. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

  6. Apr 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE3

  7. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE3

  8. Feb 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE3

  9. Jan 2024 — Feb 2024 [monthly]

    Active Not Recruiting PHASE3

  10. Dec 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE3

  11. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE3

  12. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE3

  13. Sep 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE3

  14. Aug 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE3

  15. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE3

  16. Jun 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE3

  17. May 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE3

  18. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  19. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE3

  20. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE3

  21. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE3

  22. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE3

  23. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE3

  24. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE3

  25. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE3

  26. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE3

  27. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE3

  28. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE3

  29. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE3

  30. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE3

  31. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE3

  32. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE3

  33. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE3

  34. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE3

  35. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

  36. Jun 2021 — Sep 2021 [monthly]

    Not Yet Recruiting PHASE3

  37. Apr 2021 — Jun 2021 [monthly]

    Not Yet Recruiting PHASE3

  38. Jan 2021 — Apr 2021 [monthly]

    Not Yet Recruiting PHASE3

  39. Dec 2020 — Jan 2021 [monthly]

    Not Yet Recruiting PHASE3

  40. Sep 2020 — Dec 2020 [monthly]

    Not Yet Recruiting PHASE3

  41. Jul 2020 — Sep 2020 [monthly]

    Not Yet Recruiting PHASE3

  42. Jun 2020 — Jul 2020 [monthly]

    Not Yet Recruiting PHASE3

  43. May 2020 — Jun 2020 [monthly]

    Not Yet Recruiting PHASE3

  44. Mar 2020 — May 2020 [monthly]

    Not Yet Recruiting PHASE3

  45. Feb 2020 — Mar 2020 [monthly]

    Not Yet Recruiting PHASE3

  46. Jan 2020 — Feb 2020 [monthly]

    Not Yet Recruiting PHASE3

  47. Dec 2019 — Jan 2020 [monthly]

    Not Yet Recruiting PHASE3

  48. Nov 2019 — Dec 2019 [monthly]

    Not Yet Recruiting PHASE3

  49. Sep 2019 — Nov 2019 [monthly]

    Not Yet Recruiting PHASE3

  50. Aug 2019 — Sep 2019 [monthly]

    Not Yet Recruiting PHASE3

  51. Jul 2019 — Aug 2019 [monthly]

    Not Yet Recruiting PHASE3

  52. Jun 2019 — Jul 2019 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .