deltatrials
Terminated PHASE2 INTERVENTIONAL 2-arm NCT04613453

Reducing Adolescent Suicide Risk: Safety, Efficacy, and Connectome Phenotypes of Intravenous Ketamine

Sponsor: National Institute of Mental Health (NIMH)

Conditions Adolescent Depression Adolescent Suicide
Interventions Ketamine Infusion Midazolam Infusion
Updated 16 times since 2020 Last updated: Aug 22, 2025 Started: Jan 21, 2022 Primary completion: Jul 31, 2024 Completion: Dec 3, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Terminated early due to concerns from the NIH DSMB regarding the rate of recruitment and the resulting inability to accomplish the initially approved study aims

Other terminated trials from National Institute of Mental Health (NIMH)

See all terminations from National Institute of Mental Health (NIMH)

Listed as NCT04613453, this PHASE2 trial focuses on Adolescent Depression and Adolescent Suicide and remains terminated or withdrawn. Sponsored by National Institute of Mental Health (NIMH), it has been updated 16 times since 2022, reflecting substantial change activity. Mental health research at this phase helps define safety and dosing parameters for future study.

Status Flow

~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Jun 2021 · 4 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~May 2022 · 4 months · monthly snapshot~May 2022 – ~Sep 2022 · 4 months · monthly snapshot~Sep 2022 – ~Sep 2023 · 12 months · monthly snapshot~Sep 2023 – ~Jul 2024 · 10 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshot~Jan 2025 – ~Sep 2025 · 8 months · monthly snapshot~Sep 2025 – present · 12 months · monthly snapshot

Change History

16 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated PHASE2

  2. Jan 2025 — Sep 2025 [monthly]

    Terminated PHASE2

    Status: Active Not Recruiting → Terminated

  3. Sep 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  4. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  5. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE2

▶ Show 11 earlier versions

  1. Sep 2023 — Jul 2024 [monthly]

    Recruiting PHASE2

  2. Sep 2022 — Sep 2023 [monthly]

    Recruiting PHASE2

  3. May 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  4. Jan 2022 — May 2022 [monthly]

    Recruiting PHASE2

  5. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  6. Nov 2021 — Dec 2021 [monthly]

    Not Yet Recruiting PHASE2

  7. Sep 2021 — Nov 2021 [monthly]

    Not Yet Recruiting PHASE2

  8. Jun 2021 — Sep 2021 [monthly]

    Not Yet Recruiting PHASE2

  9. Feb 2021 — Jun 2021 [monthly]

    Not Yet Recruiting PHASE2

  10. Jan 2021 — Feb 2021 [monthly]

    Not Yet Recruiting PHASE2

  11. Dec 2020 — Jan 2021 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Institute of Mental Health (NIMH)
  • Yale University
Data source: Yale University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations