deltatrials
Completed PHASE3 INTERVENTIONAL 5-arm NCT04625725

Phase III Double-blind, Placebo-controlled Study of AZD7442 for Pre-exposure Prophylaxis of COVID-19 in Adult. (PROVENT)

A Phase III Randomized, Double-blind, Placebo-controlled, Multi-center Study in Adults to Determine the Safety and Efficacy of AZD7442, a Combination Product of Two Monoclonal Antibodies (AZD8895 and AZD1061), for Pre-exposure Prophylaxis of COVID-19.

Sponsor: AstraZeneca

Conditions COVID-19
Interventions AZD7442 Placebo
Updated 15 times since 2020 Last updated: Dec 6, 2024 Started: Nov 21, 2020 Primary completion: Aug 16, 2022 Completion: Dec 8, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on COVID-19, this trial is completed. The trial is conducted by AstraZeneca and has accumulated 15 data snapshots since 2020. Infectious disease trials contribute critical data for public health response and treatment development.

Status Flow

~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Apr 2021 · 59 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Mar 2022 · 3 months · monthly snapshot~Mar 2022 – ~Jan 2023 · 10 months · monthly snapshot~Jan 2023 – ~Jun 2024 · 17 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Sep 2025 · 7 months · monthly snapshot~Sep 2025 – present · 9 months · monthly snapshot

Change History

15 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Feb 2025 — Sep 2025 [monthly]

    Completed PHASE3

  3. Sep 2024 — Feb 2025 [monthly]

    Completed PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  5. Jun 2024 — Jul 2024 [monthly]

    Completed PHASE3

    Status: Active Not RecruitingCompleted

Show 10 earlier versions
  1. Jan 2023 — Jun 2024 [monthly]

    Active Not Recruiting PHASE3

  2. Mar 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE3

  3. Dec 2021 — Mar 2022 [monthly]

    Active Not Recruiting PHASE3

  4. Sep 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE3

  5. Jun 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE3

  6. May 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  7. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE3

  8. Feb 2021 — Apr 2021 [monthly]

    Recruiting PHASE3

  9. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

  10. Dec 2020 — Jan 2021 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Nov 2020

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • AstraZeneca
  • Iqvia Pty Ltd
Data source: AstraZeneca

For direct contact, visit the study record on ClinicalTrials.gov .