deltatrials
Terminated PHASE1/PHASE2 INTERVENTIONAL 1-arm NCT04688658

Duvelisib in Combination With Nivolumab in Patients With Advanced Unresectable Melanoma

A Phase I/II Study of PI3Kγδ Inhibitor Duvelisib in Combination With Nivolumab in Patients With Advanced Unresectable Melanoma Who Have Progressed on Anti-PD1 Therapy

Sponsor: Bristol-Myers Squibb

Updated 10 times since 2021 Last updated: Dec 3, 2025 Started: Oct 6, 2021 Primary completion: Feb 22, 2024 Completion: Feb 1, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Secura Bio, Inc. discontinued support of the trial.

This PHASE1/PHASE2 trial investigates Unresectable Melanoma and is currently terminated or withdrawn. Bristol-Myers Squibb leads this study, which shows 10 recorded versions since 2021 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshotNot Yet Recruiting~Mar 2021 – ~May 2021 · 2 months · monthly snapshotNot Yet Recruiting~May 2021 – ~Sep 2021 · 4 months · monthly snapshotNot Yet Recruiting~Sep 2021 – ~May 2022 · 8 months · monthly snapshotRecruiting~May 2022 – ~Jun 2023 · 13 months · monthly snapshotRecruiting~Jun 2023 – ~Jun 2024 · 12 months · monthly snapshotRecruiting~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Jan 2026 · 16 months · monthly snapshotActive Not Recruiting~Jan 2026 – present · 6 months · monthly snapshotTerminated

Change History

10 versions recorded
  1. Jan 2026 — Present [monthly]

    Terminated PHASE1/PHASE2

    Status: Active Not RecruitingTerminated

  2. Sep 2024 — Jan 2026 [monthly]

    Active Not Recruiting PHASE1/PHASE2

    Status: RecruitingActive Not Recruiting

  3. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1/PHASE2

    Phase: PHASE1_PHASE2PHASE1/PHASE2

  4. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE1_PHASE2

  5. Jun 2023 — Jun 2024 [monthly]

    Recruiting PHASE1_PHASE2

Show 5 earlier versions
  1. May 2022 — Jun 2023 [monthly]

    Recruiting PHASE1_PHASE2

  2. Sep 2021 — May 2022 [monthly]

    Recruiting PHASE1_PHASE2

    Status: Not Yet RecruitingRecruiting

  3. May 2021 — Sep 2021 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  4. Mar 2021 — May 2021 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  5. Jan 2021 — Mar 2021 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Bristol-Myers Squibb
  • John Kirkwood
  • Secura Bio, Inc.
Data source: University of Pittsburgh

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations