An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK2 Inhibitor Therapy and Who Require Red Blood Cell Transfusions (INDEPENDENCE)
A Phase 3, Double-blind, Randomized Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomitant JAK Inhibitor Therapy and Who Require Red Blood Cell Transfusions
Sponsor: Celgene
A PHASE3 clinical study on Anemia and Myelofibrosis, this trial is ongoing. The trial is conducted by Celgene and has accumulated 40 data snapshots since 2021. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.
Status Flow
Change History
40 versions recorded-
Sep 2025 — Present [monthly]
Active Not Recruiting PHASE3
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Aug 2025 — Sep 2025 [monthly]
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▶ Show 35 earlier versions
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Sep 2024 — Feb 2025 [monthly]
Active Not Recruiting PHASE3
Status: Recruiting → Active Not Recruiting
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Jul 2024 — Sep 2024 [monthly]
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Jun 2024 — Jul 2024 [monthly]
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Nov 2023 — Dec 2023 [monthly]
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Sep 2023 — Nov 2023 [monthly]
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Aug 2023 — Sep 2023 [monthly]
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Jul 2023 — Aug 2023 [monthly]
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Jun 2023 — Jul 2023 [monthly]
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May 2023 — Jun 2023 [monthly]
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Apr 2023 — May 2023 [monthly]
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Mar 2023 — Apr 2023 [monthly]
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Feb 2023 — Mar 2023 [monthly]
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Jan 2023 — Feb 2023 [monthly]
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Dec 2022 — Jan 2023 [monthly]
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Nov 2022 — Dec 2022 [monthly]
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Sep 2022 — Nov 2022 [monthly]
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Jul 2022 — Sep 2022 [monthly]
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Jun 2022 — Jul 2022 [monthly]
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May 2022 — Jun 2022 [monthly]
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Apr 2022 — May 2022 [monthly]
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Mar 2022 — Apr 2022 [monthly]
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Feb 2022 — Mar 2022 [monthly]
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Jan 2022 — Feb 2022 [monthly]
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Dec 2021 — Jan 2022 [monthly]
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Nov 2021 — Dec 2021 [monthly]
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Oct 2021 — Nov 2021 [monthly]
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Sep 2021 — Oct 2021 [monthly]
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May 2021 — Sep 2021 [monthly]
Recruiting PHASE3
Status: Not Yet Recruiting → Recruiting
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Feb 2021 — May 2021 [monthly]
Not Yet Recruiting PHASE3
First recorded
Eligibility Summary
No eligibility information available.
Contact Information
- Celgene
For direct contact, visit the study record on ClinicalTrials.gov .
Study Locations
Aachen, Germany , Alexandroupoli, Greece , Ancona, Italy , Angers, France , Ann Arbor, United States , Aomori, Japan , Athens, Greece , Badaro Beirut, Lebanon , Baden-Warttemberg, Germany , Barcelona, Spain and 157 more locations