Trial to Assess the Safety and Efficacy of Sirolimus-Coated Balloon vs. Uncoated Standard Angioplasty for the Treatment of Below-the-knee Peripheral Arterial Disease (LIMES)
Prospective Multi-Center Randomized Controlled Trial to Evaluate the Safety and Efficacy of SiroLIMus Drug Coated Balloon Versus Non-coated Standard Angioplasty for the Treatment of Infrapopliteal Occlusions in Patients With PEripheral Arterial DiSease
Sponsor: Center for Clinical Studies Jena
Listed as NCT04772300, this NA trial focuses on Peripheral Artery Disease and remains ongoing. Sponsored by Center for Clinical Studies Jena, it has been updated 13 times since 2022, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.
Status Flow
Change History
13 versions recorded-
Jan 2026 — Present [monthly]
Active Not Recruiting NA
Status: Recruiting → Active Not Recruiting
-
Sep 2025 — Jan 2026 [monthly]
Recruiting NA
-
Sep 2024 — Sep 2025 [monthly]
Recruiting NA
-
Jul 2024 — Sep 2024 [monthly]
Recruiting NA
-
Apr 2024 — Jul 2024 [monthly]
Recruiting NA
▶ Show 8 earlier versions
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Dec 2023 — Apr 2024 [monthly]
Recruiting NA
-
Apr 2023 — Dec 2023 [monthly]
Recruiting NA
-
Nov 2022 — Apr 2023 [monthly]
Recruiting NA
-
May 2022 — Nov 2022 [monthly]
Recruiting NA
Status: Not Yet Recruiting → Recruiting
-
Dec 2021 — May 2022 [monthly]
Not Yet Recruiting NA
-
Oct 2021 — Dec 2021 [monthly]
Not Yet Recruiting NA
-
May 2021 — Oct 2021 [monthly]
Not Yet Recruiting NA
-
Mar 2021 — May 2021 [monthly]
Not Yet Recruiting NA
First recorded
Eligibility Summary
No eligibility information available.
Contact Information
- Center for Clinical Studies Jena
- Concept Medical Inc.
- CoreLab Black Forest
- Jena University Hospital
- Vascuscience
For direct contact, visit the study record on ClinicalTrials.gov .
Study Locations
Bad Krozingen, Germany , Bad Oeynhausen, Germany , Brandenburg, Germany , Coburg, Germany , Flensburg, Germany , Hamburg, Germany , Heidelberg, Germany , Jena, Germany , Leipzig, Germany , Lingen, Germany and 8 more locations