deltatrials
Recruiting PHASE1 INTERVENTIONAL 1-arm NCT04780568

Osimertinib and Tegavivint as First-Line Therapy for the Treatment of Metastatic EGFR-Mutant Non-small Cell Lung Cancer

A Phase Ib Study of AZD9291 (Osimertinib) and BC2059 (Tegavivint) as First-Line Therapy in Patients With Metastatic EGFR-Mutant Non-Small Cell Lung Cancer (NSCLC)

Sponsor: Ohio State University Comprehensive Cancer Center

Updated 7 times since 2021 Last updated: Dec 2, 2025 Started: Jan 18, 2022 Primary completion: Jul 31, 2026 Completion: Jul 31, 2029
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT04780568, this PHASE1 trial focuses on Metastatic Lung Non-Small Cell Carcinoma and Stage IV Lung Cancer AJCC v8 and remains actively recruiting participants. Sponsored by Ohio State University Comprehensive Cancer Center, it has been updated 7 times since 2022, reflecting limited change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Apr 2021 – ~Sep 2022 · 17 months · monthly snapshotNot Yet Recruiting~Sep 2022 – ~Jan 2024 · 16 months · monthly snapshotRecruiting~Jan 2024 – ~Jul 2024 · 6 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Jan 2026 · 11 months · monthly snapshotRecruiting~Jan 2026 – present · 7 months · monthly snapshotRecruiting

Change History

7 versions recorded
  1. Jan 2026 — Present [monthly]

    Recruiting PHASE1

  2. Feb 2025 — Jan 2026 [monthly]

    Recruiting PHASE1

  3. Sep 2024 — Feb 2025 [monthly]

    Recruiting PHASE1

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

  5. Jan 2024 — Jul 2024 [monthly]

    Recruiting PHASE1

Show 2 earlier versions
  1. Sep 2022 — Jan 2024 [monthly]

    Recruiting PHASE1

    Status: Not Yet RecruitingRecruiting

  2. Apr 2021 — Sep 2022 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Ohio State University Comprehensive Cancer Center
Data source: Ohio State University Comprehensive Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations