deltatrials
Recruiting PHASE1 INTERVENTIONAL 4-arm NCT04943848

rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG

A Phase I Clinical Trial of Neo-antigen Heat Shock Protein Vaccine (rHSC-DIPGVax) in Combination With Checkpoint Blockade for the Treatment of Diffuse Intrinsic Pontine Glioma (DIPG) and Diffuse Midline Glioma in Childhood

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Conditions Diffuse Intrinsic Pontine Glioma Diffuse Midline Glioma, H3 K27M-Mutant
Interventions Balstilimab Zalifrelimab rHSC-DIPGVax
Updated 10 times since 2021 Last updated: Aug 20, 2024 Started: Jan 10, 2022 Primary completion: Jun 30, 2025 Completion: Dec 31, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma, H3 K27M-Mutant, this trial is actively recruiting participants. The trial is conducted by Ann & Robert H Lurie Children's Hospital of Chicago and has accumulated 10 data snapshots since 2022. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Sep 2021 – ~Feb 2022 · 5 months · monthly snapshotNot Yet Recruiting~Feb 2022 – ~May 2022 · 3 months · monthly snapshot~May 2022 – ~Jul 2022 · 2 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Mar 2023 · 3 months · monthly snapshot~Mar 2023 – ~Oct 2023 · 7 months · monthly snapshotRecruiting~Oct 2023 – ~Jul 2024 · 9 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 23 months · monthly snapshotRecruiting

Change History

10 versions recorded

  1. Sep 2024 — Present [monthly]

    Recruiting PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

  3. Oct 2023 — Jul 2024 [monthly]

    Recruiting PHASE1

  4. Mar 2023 — Oct 2023 [monthly]

    Recruiting PHASE1

  5. Dec 2022 — Mar 2023 [monthly]

    Recruiting PHASE1

▶ Show 5 earlier versions

  1. Sep 2022 — Dec 2022 [monthly]

    Recruiting PHASE1

  2. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE1

  3. May 2022 — Jul 2022 [monthly]

    Recruiting PHASE1

  4. Feb 2022 — May 2022 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  5. Sep 2021 — Feb 2022 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Ann & Robert H Lurie Children's Hospital of Chicago
  • Children's Hospital of Orange County
  • Dana-Farber Cancer Institute
  • University of Calgary
Data source: Ann & Robert H Lurie Children's Hospital of Chicago

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations