deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 4-arm NCT05529316

A Study of Botensilimab (AGEN1181) for the Treatment of Advanced Melanoma

A Multicohort, Open Label, Phase 2 Study of Botensilimab (AGEN1181) for Treatment of Advanced Melanoma Refractory to Prior Checkpoint Inhibitor Therapy

Sponsor: Agenus Inc.

Updated 14 times since 2022 Last updated: Jan 15, 2026 Started: Dec 12, 2022 Primary completion: Feb 29, 2028 Completion: Feb 29, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Advanced Melanoma, this trial is ongoing. The trial is conducted by Agenus Inc. and has accumulated 14 data snapshots since 2022. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Apr 2023 · 3 months · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Oct 2023 · 5 months · monthly snapshot~Oct 2023 – ~Feb 2024 · 4 months · monthly snapshot~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshot~Jan 2025 – ~Apr 2025 · 3 months · monthly snapshot~Apr 2025 – ~Sep 2025 · 5 months · monthly snapshot~Sep 2025 – ~Feb 2026 · 5 months · monthly snapshot~Feb 2026 – present · 6 months · monthly snapshot

Change History

14 versions recorded
  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Sep 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Apr 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Jan 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE2

    Status: SuspendedActive Not Recruiting

  5. Sep 2024 — Jan 2025 [monthly]

    Suspended PHASE2

Show 9 earlier versions
  1. Jul 2024 — Sep 2024 [monthly]

    Suspended PHASE2

  2. Feb 2024 — Jul 2024 [monthly]

    Suspended PHASE2

    Status: RecruitingSuspended

  3. Oct 2023 — Feb 2024 [monthly]

    Recruiting PHASE2

  4. May 2023 — Oct 2023 [monthly]

    Recruiting PHASE2

  5. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE2

  6. Jan 2023 — Apr 2023 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  7. Dec 2022 — Jan 2023 [monthly]

    Not Yet Recruiting PHASE2

  8. Nov 2022 — Dec 2022 [monthly]

    Not Yet Recruiting PHASE2

  9. Sep 2022 — Nov 2022 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Agenus Inc.
Data source: Agenus Inc.

For direct contact, visit the study record on ClinicalTrials.gov .