Combination Therapy for the Treatment of Diffuse Midline Gliomas (PNOC022)
A Combination Therapy Trial Using an Adaptive Platform Design for Children and Young Adults With Diffuse Midline Gliomas (DMGs) Including Diffuse Intrinsic Pontine Gliomas (DIPGs) at Initial Diagnosis, Post-Radiation Therapy and at Time of Progression
Sponsor: CV Biomanufacturing
A PHASE2 clinical study on Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma, H3 K27M-Mutant, this trial is actively recruiting participants. The trial is conducted by CV Biomanufacturing and has accumulated 25 data snapshots since 2021. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.
Status Flow
Change History
25 versions recorded-
Jan 2026 — Present [monthly]
Recruiting PHASE2
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Sep 2025 — Jan 2026 [monthly]
Recruiting PHASE2
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Aug 2025 — Sep 2025 [monthly]
Recruiting PHASE2
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Jun 2025 — Aug 2025 [monthly]
Recruiting PHASE2
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May 2025 — Jun 2025 [monthly]
Recruiting PHASE2
▶ Show 20 earlier versions
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Jan 2025 — May 2025 [monthly]
Recruiting PHASE2
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Sep 2024 — Jan 2025 [monthly]
Recruiting PHASE2
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Jul 2024 — Sep 2024 [monthly]
Recruiting PHASE2
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Jun 2024 — Jul 2024 [monthly]
Recruiting PHASE2
Status: Active Not Recruiting → Recruiting
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Dec 2023 — Jun 2024 [monthly]
Active Not Recruiting PHASE2
Status: Recruiting → Active Not Recruiting
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Jun 2023 — Dec 2023 [monthly]
Recruiting PHASE2
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Apr 2023 — Jun 2023 [monthly]
Recruiting PHASE2
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Mar 2023 — Apr 2023 [monthly]
Recruiting PHASE2
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Feb 2023 — Mar 2023 [monthly]
Recruiting PHASE2
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Jan 2023 — Feb 2023 [monthly]
Recruiting PHASE2
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Dec 2022 — Jan 2023 [monthly]
Recruiting PHASE2
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Nov 2022 — Dec 2022 [monthly]
Recruiting PHASE2
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Sep 2022 — Nov 2022 [monthly]
Recruiting PHASE2
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Jul 2022 — Sep 2022 [monthly]
Recruiting PHASE2
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Jun 2022 — Jul 2022 [monthly]
Recruiting PHASE2
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May 2022 — Jun 2022 [monthly]
Recruiting PHASE2
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Mar 2022 — May 2022 [monthly]
Recruiting PHASE2
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Nov 2021 — Mar 2022 [monthly]
Recruiting PHASE2
Status: Not Yet Recruiting → Recruiting
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Oct 2021 — Nov 2021 [monthly]
Not Yet Recruiting PHASE2
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Sep 2021 — Oct 2021 [monthly]
Not Yet Recruiting PHASE2
First recorded
Eligibility Summary
No eligibility information available.
Contact Information
- CV Biomanufacturing
- Jazz Pharmaceuticals
- Mithil Prasad Foundation
- National Institute of Neurological Disorders and Stroke (NINDS)
- Neeve Kolte and Brave Ronil Foundation
- Storm the Heavens Fund
- The Chad-Tough Defeat DIPG Foundation
- University of California, San Francisco
- Will Meeker Foundation
For direct contact, visit the study record on ClinicalTrials.gov .