deltatrials
Active Not Recruiting PHASE3 INTERVENTIONAL 2-arm NCT05026866

A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer's Disease (TRAILBLAZER-ALZ 3)

A Study of Donanemab Versus Placebo in Participants at Risk for Cognitive and Functional Decline of Alzheimer's Disease

Sponsor: Eli Lilly and Company

Updated 42 times since 2021 Last updated: Jan 19, 2026 Started: Aug 27, 2021 Primary completion: Nov 30, 2027 Completion: Nov 30, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Alzheimer Disease and is currently ongoing. Eli Lilly and Company leads this study, which shows 42 recorded versions since 2021 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Apr 2022 · 59 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Nov 2023 · 2 months · monthly snapshot~Nov 2023 – ~Feb 2024 · 3 months · monthly snapshot~Feb 2024 – ~Apr 2024 · 2 months · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Jan 2025 · 2 months · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~May 2025 · 2 months · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Sep 2025 · 2 months · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – ~Jan 2026 · 2 months · monthly snapshot~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

42 versions recorded
  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE3

  2. Jan 2026 — Feb 2026 [monthly]

    Active Not Recruiting PHASE3

  3. Nov 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  4. Sep 2025 — Nov 2025 [monthly]

    Recruiting PHASE3

  5. Jul 2025 — Sep 2025 [monthly]

    Recruiting PHASE3

Show 37 earlier versions
  1. Jun 2025 — Jul 2025 [monthly]

    Recruiting PHASE3

  2. May 2025 — Jun 2025 [monthly]

    Recruiting PHASE3

  3. Mar 2025 — May 2025 [monthly]

    Recruiting PHASE3

    Status: Active Not RecruitingRecruiting

  4. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Jan 2025 — Feb 2025 [monthly]

    Active Not Recruiting PHASE3

  6. Nov 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE3

  7. Oct 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE3

  8. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  9. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE3

  10. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE3

  11. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE3

  12. May 2024 — Jun 2024 [monthly]

    Recruiting PHASE3

  13. Apr 2024 — May 2024 [monthly]

    Recruiting PHASE3

  14. Feb 2024 — Apr 2024 [monthly]

    Recruiting PHASE3

  15. Nov 2023 — Feb 2024 [monthly]

    Recruiting PHASE3

  16. Sep 2023 — Nov 2023 [monthly]

    Recruiting PHASE3

  17. Aug 2023 — Sep 2023 [monthly]

    Recruiting PHASE3

  18. Jul 2023 — Aug 2023 [monthly]

    Recruiting PHASE3

  19. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE3

  20. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE3

  21. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE3

  22. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE3

  23. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE3

  24. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE3

  25. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE3

  26. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE3

  27. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE3

  28. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE3

  29. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE3

  30. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE3

  31. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE3

  32. Feb 2022 — Apr 2022 [monthly]

    Recruiting PHASE3

  33. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE3

  34. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE3

  35. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE3

  36. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

  37. Sep 2021 — Oct 2021 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Aug 2021

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Eli Lilly and Company
Data source: Eli Lilly and Company

For direct contact, visit the study record on ClinicalTrials.gov .