deltatrials
Active Not Recruiting PHASE1 INTERVENTIONAL 1-arm NCT05176470

Neoadj Admin Autologous Tumor Infiltrating Lymphocytes & Pembrolizumab for Treatment of Adv Melanoma Patients

A Phase IB Study to Assess the Safety and Efficacy of Neoadjuvant Administration of Autologous Tumor Infiltrating Lymphocytes (LN144/Lifileucel) and Pembrolizumab for Treatment of Patients With Locally Advanced (Stage IIIB-D)/Metastatic (Stage IV) Melanoma

Sponsor: Iovance Biotherapeutics, Inc.

Updated 9 times since 2022 Last updated: Feb 20, 2026 Started: Jul 1, 2022 Primary completion: Jul 14, 2023 Completion: Dec 31, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Locally Advanced Melanoma and Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 and is currently ongoing. Iovance Biotherapeutics, Inc. leads this study, which shows 9 recorded versions since 2022 — indicating limited longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2022 – ~Mar 2022 · 59 days · monthly snapshot~Mar 2022 – ~May 2022 · 2 months · monthly snapshot~May 2022 – ~Nov 2022 · 6 months · monthly snapshotRecruiting~Nov 2022 – ~Apr 2024 · 17 months · monthly snapshotRecruiting~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshotActive Not Recruiting~Feb 2025 – ~Feb 2026 · 12 months · monthly snapshotActive Not Recruiting~Feb 2026 – present · 5 months · monthly snapshotActive Not Recruiting

Change History

9 versions recorded
  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE1

  2. Feb 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE1

  3. Sep 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Apr 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

    Status: RecruitingActive Not Recruiting

Show 4 earlier versions
  1. Nov 2022 — Apr 2024 [monthly]

    Recruiting PHASE1

    Phase: PHASE1_PHASE2PHASE1

  2. May 2022 — Nov 2022 [monthly]

    Recruiting PHASE1_PHASE2

    Status: Not Yet RecruitingRecruiting

  3. Mar 2022 — May 2022 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

  4. Jan 2022 — Mar 2022 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Iovance Biotherapeutics, Inc.
  • Richard Wu
Data source: Ohio State University Comprehensive Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations