Active Not Recruiting OBSERVATIONAL NCT05677594

Multi-parametric Biomarker Development to Predict Malignant Conversion in Patients With Neurofibromatosis Type 1

Sponsor: Johns Hopkins University

Conditions Atypical Neurofibroma Malignant Peripheral Nerve Sheath Tumor (MPNST) of Soft Tissue (Diagnosis) Neurofibromatosis 1

Interventions Whole Body Magnetic Resonance Imaging

Updated 7 times since 2023 Last updated: Jan 9, 2026 Started: Jul 1, 2021 Primary completion: Jun 30, 2028 Completion: Jun 30, 2028

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A observational or N/A phase clinical study on Atypical Neurofibroma and Malignant Peripheral Nerve Sheath Tumor (MPNST) of Soft Tissue (Diagnosis), this trial is ongoing. The trial is conducted by Johns Hopkins University and has accumulated 7 data snapshots since 2021. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

Change History

7 versions recorded

Feb 2026 — Present [monthly]

Active Not Recruiting
Feb 2025 — Feb 2026 [monthly]

Active Not Recruiting
Jan 2025 — Feb 2025 [monthly]

Active Not Recruiting

Status: Recruiting → Active Not Recruiting
Sep 2024 — Jan 2025 [monthly]

Recruiting
Jul 2024 — Sep 2024 [monthly]

Recruiting

▶ Show 2 earlier versions

Jan 2024 — Jul 2024 [monthly]

Recruiting
Feb 2023 — Jan 2024 [monthly]

Recruiting

First recorded

Jul 2021

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Johns Hopkins University
Neurofibromatosis Therapeutic Acceleration Program

Data source: Johns Hopkins University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Baltimore, United States