deltatrials
Recruiting PHASE2 INTERVENTIONAL 2-arm NCT05941520

Acolbifene Versus Low Dose Tamoxifen for the Prevention of Breast Cancer in Premenopausal Women at High Risk for Development of Breast Cancer

Phase IIA Trial of Acolbifene (20 mg) vs Low Dose Tamoxifen (5 mg) in Pre-menopausal Women at High Risk for Development of Breast Cancer

Sponsor: National Cancer Institute (NCI)

Updated 16 times since 2023 Last updated: Mar 12, 2026 Started: Aug 23, 2024 Primary completion: Aug 23, 2027 Completion: Sep 1, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT05941520, this PHASE2 trial focuses on Breast Atypical Hyperplasia and Breast Carcinoma and remains actively recruiting participants. Sponsored by National Cancer Institute (NCI), it has been updated 16 times since 2024, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~May 2024 · 6 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Mar 2025 · 5 months · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Nov 2025 · 5 months · monthly snapshot~Nov 2025 – ~Jan 2026 · 2 months · monthly snapshot~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshot~Feb 2026 – ~Mar 2026 · 28 days · monthly snapshot~Mar 2026 – present · 5 months · monthly snapshot

Change History

16 versions recorded
  1. Mar 2026 — Present [monthly]

    Recruiting PHASE2

  2. Feb 2026 — Mar 2026 [monthly]

    Recruiting PHASE2

  3. Jan 2026 — Feb 2026 [monthly]

    Recruiting PHASE2

  4. Nov 2025 — Jan 2026 [monthly]

    Recruiting PHASE2

  5. Jun 2025 — Nov 2025 [monthly]

    Recruiting PHASE2

Show 11 earlier versions
  1. May 2025 — Jun 2025 [monthly]

    Recruiting PHASE2

  2. Apr 2025 — May 2025 [monthly]

    Recruiting PHASE2

  3. Mar 2025 — Apr 2025 [monthly]

    Recruiting PHASE2

  4. Oct 2024 — Mar 2025 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  5. Sep 2024 — Oct 2024 [monthly]

    Not Yet Recruiting PHASE2

  6. Jul 2024 — Sep 2024 [monthly]

    Not Yet Recruiting PHASE2

  7. May 2024 — Jul 2024 [monthly]

    Not Yet Recruiting PHASE2

  8. Nov 2023 — May 2024 [monthly]

    Not Yet Recruiting PHASE2

  9. Oct 2023 — Nov 2023 [monthly]

    Not Yet Recruiting PHASE2

  10. Sep 2023 — Oct 2023 [monthly]

    Not Yet Recruiting PHASE2

  11. Aug 2023 — Sep 2023 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .