Recruiting PHASE2 INTERVENTIONAL 3-arm NCT06223360

A Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)

A Seamless Phase 2A-Phase 2B Randomized Double-Blind Placebo- Controlled Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)

Sponsor: Alzheimer's Disease Cooperative Study (ADCS)

Conditions Alzheimer Disease

Interventions High Dose Benfotiamine Low Dose Benfotiamine Placebo

Updated 15 times since 2024 Last updated: Feb 20, 2026 Started: Mar 28, 2024 Primary completion: Dec 1, 2027 Completion: Dec 1, 2027

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Alzheimer Disease, this trial is actively recruiting participants. The trial is conducted by Alzheimer's Disease Cooperative Study (ADCS) and has accumulated 15 data snapshots since 2024. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

Change History

15 versions recorded

Feb 2026 — Present [monthly]

Recruiting PHASE2
Jan 2026 — Feb 2026 [monthly]

Recruiting PHASE2
Dec 2025 — Jan 2026 [monthly]

Recruiting PHASE2
Nov 2025 — Dec 2025 [monthly]

Recruiting PHASE2
Sep 2025 — Nov 2025 [monthly]

Recruiting PHASE2

▶ Show 10 earlier versions

Aug 2025 — Sep 2025 [monthly]

Recruiting PHASE2
Jul 2025 — Aug 2025 [monthly]

Recruiting PHASE2
Apr 2025 — Jul 2025 [monthly]

Recruiting PHASE2
Jan 2025 — Apr 2025 [monthly]

Recruiting PHASE2
Sep 2024 — Jan 2025 [monthly]

Recruiting PHASE2
Jul 2024 — Sep 2024 [monthly]

Recruiting PHASE2
May 2024 — Jul 2024 [monthly]

Recruiting PHASE2

Status: Not Yet Recruiting → Recruiting
Apr 2024 — May 2024 [monthly]

Not Yet Recruiting PHASE2
Mar 2024 — Apr 2024 [monthly]

Not Yet Recruiting PHASE2
Feb 2024 — Mar 2024 [monthly]

Not Yet Recruiting PHASE2

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Alzheimer's Disease Cooperative Study (ADCS)
Burke Medical Research Institute
National Institute on Aging (NIA)

Data source: Alzheimer's Disease Cooperative Study (ADCS)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Albany, United States , Amherst, United States , Ann Arbor, United States , Atlanta, United States , Atlantis, United States , Brooklyn, United States , Charleston, United States , Chicago, United States , Chula Vista, United States , Cleveland, United States and 28 more locations