Recruiting PHASE1/PHASE2 INTERVENTIONAL 4-arm NCT06228326

A Study Assessing KB707 for the Treatment of Advanced Solid Tumor Malignancies Affecting the Lungs (KYANITE-1)

KB707-02: A Phase 1/2 Study of Inhaled KB707 in Patients With Advanced Solid Tumor Malignancies Affecting the Lungs

Sponsor: Krystal Biotech, Inc.

Conditions Advanced Cancer Lung Cancer (NSCLC) Lung Cancer Metastatic Lung Cancer, Non-small Cell Solid Tumor, Adult

Interventions Chemotherapy Docetaxel KB707 Pembrolizumab (KEYTRUDA®)

Updated 11 times since 2024 Last updated: Oct 22, 2025 Started: Apr 17, 2024 Primary completion: Feb 28, 2027 Completion: Jul 31, 2028

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT06228326, this PHASE1/PHASE2 trial focuses on Advanced Cancer and Lung Cancer (NSCLC) and remains actively recruiting participants. Sponsored by Krystal Biotech, Inc., it has been updated 11 times since 2024, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

Change History

11 versions recorded

Nov 2025 — Present [monthly]

Recruiting PHASE1/PHASE2
Jun 2025 — Nov 2025 [monthly]

Recruiting PHASE1/PHASE2
Mar 2025 — Jun 2025 [monthly]

Recruiting PHASE1/PHASE2
Dec 2024 — Mar 2025 [monthly]

Recruiting PHASE1/PHASE2

Phase: PHASE1 → PHASE1/PHASE2
Nov 2024 — Dec 2024 [monthly]

Recruiting PHASE1

▶ Show 6 earlier versions

Oct 2024 — Nov 2024 [monthly]

Recruiting PHASE1
Sep 2024 — Oct 2024 [monthly]

Recruiting PHASE1
Jul 2024 — Sep 2024 [monthly]

Recruiting PHASE1
Jun 2024 — Jul 2024 [monthly]

Recruiting PHASE1
May 2024 — Jun 2024 [monthly]

Recruiting PHASE1
Feb 2024 — May 2024 [monthly]

Recruiting PHASE1

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Krystal Biotech, Inc.

Data source: Krystal Biotech, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Beverly Hills, United States , Canton, United States , Cleveland, United States , Detroit, United States , Dothan, United States , El Paso, United States , Indianapolis, United States , Nasville, United States , New Orleans, United States , Pittsburgh, United States and 4 more locations