A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
A Phase 3, Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-3)
Sponsor: Bristol-Myers Squibb
Listed as NCT06937229, this observational or N/A phase trial focuses on Agitation and Alzheimer Disease and remains actively recruiting participants. Sponsored by Bristol-Myers Squibb, it has been updated 10 times since 2025, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.
Status Flow
Change History
10 versions recorded-
Apr 21, 2026 — Present [daily]
Recruiting
Phase: PHASE3 → None
-
Feb 2026 — Apr 2026 [monthly]
Recruiting PHASE3
Status: Not Yet Recruiting → Recruiting
-
Dec 2025 — Feb 2026 [monthly]
Not Yet Recruiting PHASE3
-
Nov 2025 — Dec 2025 [monthly]
Not Yet Recruiting PHASE3
-
Oct 2025 — Nov 2025 [monthly]
Not Yet Recruiting PHASE3
▶ Show 5 earlier versions
-
Sep 2025 — Oct 2025 [monthly]
Not Yet Recruiting PHASE3
-
Aug 2025 — Sep 2025 [monthly]
Not Yet Recruiting PHASE3
-
Jul 2025 — Aug 2025 [monthly]
Not Yet Recruiting PHASE3
-
Jun 2025 — Jul 2025 [monthly]
Not Yet Recruiting PHASE3
-
May 2025 — Jun 2025 [monthly]
Not Yet Recruiting PHASE3
First recorded
Eligibility Summary
The purpose of this study is to evaluate the long-term efficacy and safety of combined formulation of xanomeline tartrate/trospium chloride in an immediate release (IR) capsule (KarXT) and xanomeline enteric capsules (KarX-EC) in participants with agitation associated with Alzheimer's Disease who completed the parent studies CN012-0023 or CN012-0024.
Contact Information
- Bristol-Myers Squibb
For direct contact, visit the study record on ClinicalTrials.gov .
Study Locations
Ahmedabad, India , Anaheim, United States , Ann Arbor, United States , Antofagasta, Chile , Athens, Greece , Athens, Greece , Athens, Greece , Athens, Greece , Athens, Greece , Bennington, United States and 231 more locations