Completed PHASE1/PHASE2 INTERVENTIONAL 4-arm NCT00068250

Combination Chemotherapy, Monoclonal Antibody, and Radiation Therapy in Treating Patients With Primary Central Nervous System Lymphoma

Phase I/II Study Of Pre-Irradiation Chemotherapy With Methotrexate, Rituximab, And Temozolomide And Post -Irradiation Temozolomide For Primary Central Nervous System Lymphoma

Sponsor: NRG Oncology

Conditions Brain and Central Nervous System Tumors Lymphoma

Interventions methotrexate post-radiation therapy temozolomide radiation therapy rituximab temozolomide 100 mg/m^2 temozolomide 150 mg/m^2 temozolomide 200 mg/m^2

Updated 9 times since 2017 Last updated: Feb 1, 2018 Started: Jul 31, 2003 Primary completion: Dec 31, 2016 Completion: Dec 31, 2016

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1/PHASE2 trial investigates Brain and Central Nervous System Tumors and Lymphoma and is currently completed. NRG Oncology leads this study, which shows 9 recorded versions since 2003 — indicating limited longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

Change History

9 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE1/PHASE2
Sep 2024 — Sep 2025 [monthly]

Completed PHASE1/PHASE2
Jul 2024 — Sep 2024 [monthly]

Completed PHASE1/PHASE2

Phase: PHASE1_PHASE2 → PHASE1/PHASE2
Dec 2021 — Jul 2024 [monthly]

Completed PHASE1_PHASE2
Jan 2021 — Dec 2021 [monthly]

Completed PHASE1_PHASE2

▶ Show 4 earlier versions

Jun 2018 — Jan 2021 [monthly]

Completed PHASE1_PHASE2
Mar 2018 — Jun 2018 [monthly]

Completed PHASE1_PHASE2
Feb 2017 — Mar 2018 [monthly]

Completed PHASE1_PHASE2
Jan 2017 — Feb 2017 [monthly]

Completed PHASE1_PHASE2

First recorded

Jul 2003

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

NRG Oncology
National Cancer Institute (NCI)
Radiation Therapy Oncology Group

Data source: Radiation Therapy Oncology Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Charleston, United States , Cleveland, United States , Edison, United States , Jacksonville, United States , Jacksonville Beach, United States , Kalamazoo, United States , Kansas City, United States , Las Vegas, United States , Menomonee Falls, United States , Milwaukee, United States and 10 more locations