deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 2-arm NCT02628067

Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)

A Clinical Trial of Pembrolizumab (MK-3475) Evaluating Predictive Biomarkers in Subjects With Advanced Solid Tumors (KEYNOTE 158)

Sponsor: Merck Sharp & Dohme LLC

Conditions Advanced Cancer Advanced Solid Tumors Anal Cancer Anal Carcinoma Bile Duct Cancer Biliary Cancer Carcinoid Tumor Cervical Cancer Cervical Carcinoma Cholangiocarcinoma Colorectal Carcinoma Endometrial Cancer Endometrial Carcinoma Mesothelioma Neuroendocrine Tumor Parotid Gland Cancer Salivary Cancer Salivary Gland Cancer Salivary Gland Carcinoma Small Cell Lung Cancer (SCLC) Small Cell Lung Carcinoma Thyroid Cancer Thyroid Carcinoma Vulvar Cancer Vulvar Carcinoma
Interventions pembrolizumab
Updated 54 times since 2017 Last updated: Sep 18, 2025 Started: Dec 18, 2015 Primary completion: May 4, 2027 Completion: May 4, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Advanced Cancer and Advanced Solid Tumors, this trial is ongoing. The trial is conducted by Merck Sharp & Dohme LLC and has accumulated 54 data snapshots since 2015. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Jul 2017 · 4 months · monthly snapshot~Jul 2017 – ~Jan 2018 · 6 months · monthly snapshot~Jan 2018 – ~Feb 2018 · 31 days · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Oct 2018 · 3 months · monthly snapshot~Oct 2018 – ~Feb 2019 · 4 months · monthly snapshot~Feb 2019 – ~Apr 2019 · 59 days · monthly snapshot~Apr 2019 – ~Jun 2019 · 2 months · monthly snapshot~Jun 2019 – ~Aug 2019 · 2 months · monthly snapshot~Aug 2019 – ~Jan 2020 · 5 months · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Jun 2020 · 3 months · monthly snapshot~Jun 2020 – ~Aug 2020 · 2 months · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~Jun 2021 · 2 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Jan 2022 · 2 months · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~May 2022 · 3 months · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~Jun 2023 · 2 months · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Dec 2023 · 4 months · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Mar 2024 · 2 months · monthly snapshot~Mar 2024 – ~May 2024 · 2 months · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Jun 2025 · 6 months · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – present · 9 months · monthly snapshot

Change History

54 versions recorded

  1. Oct 2025 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  4. Jul 2025 — Aug 2025 [monthly]

    Recruiting PHASE2

  5. Jun 2025 — Jul 2025 [monthly]

    Recruiting PHASE2

▶ Show 49 earlier versions

  1. Dec 2024 — Jun 2025 [monthly]

    Recruiting PHASE2

  2. Nov 2024 — Dec 2024 [monthly]

    Recruiting PHASE2

  3. Sep 2024 — Nov 2024 [monthly]

    Recruiting PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  5. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

  6. May 2024 — Jun 2024 [monthly]

    Recruiting PHASE2

  7. Mar 2024 — May 2024 [monthly]

    Recruiting PHASE2

  8. Jan 2024 — Mar 2024 [monthly]

    Recruiting PHASE2

  9. Dec 2023 — Jan 2024 [monthly]

    Recruiting PHASE2

  10. Aug 2023 — Dec 2023 [monthly]

    Recruiting PHASE2

  11. Jul 2023 — Aug 2023 [monthly]

    Recruiting PHASE2

  12. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE2

  13. Apr 2023 — Jun 2023 [monthly]

    Recruiting PHASE2

  14. Feb 2023 — Apr 2023 [monthly]

    Recruiting PHASE2

  15. Dec 2022 — Feb 2023 [monthly]

    Recruiting PHASE2

  16. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE2

  17. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE2

  18. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  19. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  20. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE2

  21. Feb 2022 — May 2022 [monthly]

    Recruiting PHASE2

  22. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE2

  23. Nov 2021 — Jan 2022 [monthly]

    Recruiting PHASE2

  24. Sep 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  25. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  26. Apr 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

  27. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  28. Jan 2021 — Mar 2021 [monthly]

    Recruiting PHASE2

  29. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  30. Oct 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

  31. Aug 2020 — Oct 2020 [monthly]

    Recruiting PHASE2

  32. Jun 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  33. Mar 2020 — Jun 2020 [monthly]

    Recruiting PHASE2

  34. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE2

  35. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE2

  36. Aug 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  37. Jun 2019 — Aug 2019 [monthly]

    Recruiting PHASE2

  38. Apr 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

  39. Feb 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  40. Oct 2018 — Feb 2019 [monthly]

    Recruiting PHASE2

  41. Jul 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  42. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2

  43. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  44. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE2

  45. Jan 2018 — Feb 2018 [monthly]

    Recruiting PHASE2

  46. Jul 2017 — Jan 2018 [monthly]

    Recruiting PHASE2

  47. Mar 2017 — Jul 2017 [monthly]

    Recruiting PHASE2

  48. Feb 2017 — Mar 2017 [monthly]

    Recruiting PHASE2

  49. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Dec 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Merck Sharp & Dohme LLC
Data source: Merck Sharp & Dohme LLC

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

No location information available.