deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 1-arm NCT03212274

Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations

A Phase 2 Study of the PARP Inhibitor Olaparib (AZD2281) in IDH1 and IDH2 Mutant Advanced Solid Tumors

Sponsor: National Cancer Institute (NCI)

Conditions Advanced Malignant Solid Neoplasm Glioblastoma Recurrent Cholangiocarcinoma Recurrent Glioma Recurrent Malignant Solid Neoplasm WHO Grade 2 Glioma WHO Grade 3 Glioma
Interventions Biopsy Procedure Biospecimen Collection Computed Tomography Magnetic Resonance Imaging Olaparib
Updated 74 times since 2017 Last updated: Feb 18, 2026 Started: Jan 30, 2019 Primary completion: Apr 2, 2025 Completion: Jul 28, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Advanced Malignant Solid Neoplasm and Glioblastoma and is currently ongoing. National Cancer Institute (NCI) leads this study, which shows 74 recorded versions since 2019 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Aug 2017 – ~Mar 2018 · 7 months · monthly snapshot~Mar 2018 – ~May 2018 · 2 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Jan 2019 · 4 months · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Nov 2020 · 2 months · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Feb 2022 · 2 months · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Jan 2023 · 2 months · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Sep 2023 · 4 months · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~Jun 2024 · 2 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Feb 2025 · 3 months · monthly snapshot~Feb 2025 – ~May 2025 · 3 months · monthly snapshot~May 2025 – ~Jul 2025 · 2 months · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Dec 2025 · 2 months · monthly snapshot~Dec 2025 – ~Feb 2026 · 2 months · monthly snapshot~Feb 2026 – present · 6 months · monthly snapshot

Change History

74 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Dec 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Oct 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

▶ Show 69 earlier versions

  1. Jul 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE2

  2. May 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Feb 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Nov 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE2

  6. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  7. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE2

  8. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  9. Apr 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE2

  10. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  11. Feb 2024 — Mar 2024 [monthly]

    Recruiting PHASE2

  12. Jan 2024 — Feb 2024 [monthly]

    Recruiting PHASE2

  13. Dec 2023 — Jan 2024 [monthly]

    Recruiting PHASE2

  14. Nov 2023 — Dec 2023 [monthly]

    Recruiting PHASE2

  15. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE2

  16. Sep 2023 — Oct 2023 [monthly]

    Recruiting PHASE2

  17. May 2023 — Sep 2023 [monthly]

    Recruiting PHASE2

  18. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE2

  19. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE2

  20. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE2

  21. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE2

  22. Nov 2022 — Jan 2023 [monthly]

    Recruiting PHASE2

  23. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE2

  24. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  25. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  26. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE2

  27. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE2

  28. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE2

  29. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE2

  30. Dec 2021 — Feb 2022 [monthly]

    Recruiting PHASE2

  31. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

  32. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  33. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  34. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  35. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

  36. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE2

  37. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  38. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE2

  39. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  40. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  41. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

  42. Sep 2020 — Nov 2020 [monthly]

    Recruiting PHASE2

  43. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

  44. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  45. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE2

  46. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE2

  47. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE2

  48. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  49. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE2

  50. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE2

  51. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  52. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  53. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  54. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

  55. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  56. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE2

  57. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  58. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

  59. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE2

  60. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  61. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE2

  62. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE2

    Status: Suspended → Recruiting

  63. Sep 2018 — Jan 2019 [monthly]

    Suspended PHASE2

  64. Aug 2018 — Sep 2018 [monthly]

    Suspended PHASE2

  65. Jul 2018 — Aug 2018 [monthly]

    Suspended PHASE2

    Status: Recruiting → Suspended

  66. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2

  67. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  68. Mar 2018 — May 2018 [monthly]

    Not Yet Recruiting PHASE2

  69. Aug 2017 — Mar 2018 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Atlanta, United States , Baltimore, United States , Boston, United States , Chapel Hill, United States , City of Saint Peters, United States , Columbus, United States , Coral Gables, United States , Costa Mesa, United States , Creve Coeur, United States , Deerfield Beach, United States and 28 more locations