PRISM Study-Pruritus Relief Through Itch Scratch Modulation (PRISM)
A Phase 2b/3, Randomized, Double-Blind, Placebo-Controlled, 2-Arm, Efficacy and Safety Study in Prurigo Nodularis (PN) With Nalbuphine ER Tablets for Pruritus Relief Through Itch Scratch Modulation (PRISM Study)
Sponsor: Trevi Therapeutics
Listed as NCT03497975, this PHASE2/PHASE3 trial focuses on Prurigo Nodularis and remains completed. Sponsored by Trevi Therapeutics, it has been updated 25 times since 2018, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.
Status Flow
Change History
25 versions recorded-
Sep 2025 — Present [monthly]
Completed PHASE2/PHASE3
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Jul 2025 — Sep 2025 [monthly]
Completed PHASE2/PHASE3
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Sep 2024 — Jul 2025 [monthly]
Completed PHASE2/PHASE3
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Jul 2024 — Sep 2024 [monthly]
Completed PHASE2/PHASE3
Phase: PHASE2_PHASE3 → PHASE2/PHASE3
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Jun 2023 — Jul 2024 [monthly]
Completed PHASE2_PHASE3
▶ Show 20 earlier versions
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May 2023 — Jun 2023 [monthly]
Completed PHASE2_PHASE3
Status: Active Not Recruiting → Completed
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Mar 2023 — May 2023 [monthly]
Active Not Recruiting PHASE2_PHASE3
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Feb 2023 — Mar 2023 [monthly]
Active Not Recruiting PHASE2_PHASE3
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Dec 2022 — Feb 2023 [monthly]
Active Not Recruiting PHASE2_PHASE3
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Nov 2022 — Dec 2022 [monthly]
Active Not Recruiting PHASE2_PHASE3
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Sep 2022 — Nov 2022 [monthly]
Active Not Recruiting PHASE2_PHASE3
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Mar 2022 — Sep 2022 [monthly]
Active Not Recruiting PHASE2_PHASE3
Status: Recruiting → Active Not Recruiting
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Oct 2021 — Mar 2022 [monthly]
Recruiting PHASE2_PHASE3
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Sep 2021 — Oct 2021 [monthly]
Recruiting PHASE2_PHASE3
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May 2021 — Sep 2021 [monthly]
Recruiting PHASE2_PHASE3
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Apr 2021 — May 2021 [monthly]
Recruiting PHASE2_PHASE3
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Feb 2021 — Apr 2021 [monthly]
Recruiting PHASE2_PHASE3
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Jan 2021 — Feb 2021 [monthly]
Recruiting PHASE2_PHASE3
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Oct 2020 — Jan 2021 [monthly]
Recruiting PHASE2_PHASE3
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Sep 2020 — Oct 2020 [monthly]
Recruiting PHASE2_PHASE3
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Apr 2020 — Sep 2020 [monthly]
Recruiting PHASE2_PHASE3
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Aug 2019 — Apr 2020 [monthly]
Recruiting PHASE2_PHASE3
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Sep 2018 — Aug 2019 [monthly]
Recruiting PHASE2_PHASE3
Status: Not Yet Recruiting → Recruiting
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Jun 2018 — Sep 2018 [monthly]
Not Yet Recruiting PHASE2_PHASE3
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May 2018 — Jun 2018 [monthly]
Not Yet Recruiting PHASE2_PHASE3
First recorded
Eligibility Summary
No eligibility information available.
Contact Information
- Trevi Therapeutics
For direct contact, visit the study record on ClinicalTrials.gov .