deltatrials
Recruiting PHASE2 NCT04080804

Study of Safety and Tolerability of Nivolumab Treatment Alone or in Combination With Relatlimab or Ipilimumab in Head and Neck Cancer

A Phase II Neoadjuvant Study of the Safety and Tolerability of Anti-PD1 (Nivolumab) Administered Alone or in Combination With Anti-LAG3 (Relatlimab) or Anti-CTLA4 (Ipilimumab) in Resectable Head and Neck Cancer

Sponsor: Bristol-Myers Squibb

Updated 19 times since 2019 Last updated: Feb 4, 2026 Started: Dec 20, 2019 Primary completion: Jun 30, 2026 Completion: Oct 31, 2026

This PHASE2 trial investigates Head and Neck Squamous Cell Carcinoma (HNSCC) and is currently actively recruiting participants. Bristol-Myers Squibb leads this study, which shows 19 recorded versions since 2019 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Feb 2020 · 2 months · monthly snapshot~Feb 2020 – ~Apr 2020 · 2 months · monthly snapshot~Apr 2020 – ~Aug 2020 · 4 months · monthly snapshot~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshot~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Nov 2021 · 6 months · monthly snapshot~Nov 2021 – ~May 2022 · 6 months · monthly snapshot~May 2022 – ~Jun 2023 · 13 months · monthly snapshot~Jun 2023 – ~Aug 2023 · 2 months · monthly snapshot~Aug 2023 – ~Jan 2024 · 5 months · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Jan 2025 · 2 months · monthly snapshot~Jan 2025 – ~Feb 2026 · 13 months · monthly snapshot~Feb 2026 – present · 48 days · monthly snapshot

Change History

19 versions recorded
  1. Feb 2026 — Present [monthly]

    Recruiting PHASE2

  2. Jan 2025 — Feb 2026 [monthly]

    Recruiting PHASE2

  3. Nov 2024 — Jan 2025 [monthly]

    Recruiting PHASE2

  4. Sep 2024 — Nov 2024 [monthly]

    Recruiting PHASE2

  5. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

Show 14 earlier versions
  1. Feb 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

  2. Jan 2024 — Feb 2024 [monthly]

    Recruiting PHASE2

  3. Aug 2023 — Jan 2024 [monthly]

    Recruiting PHASE2

  4. Jun 2023 — Aug 2023 [monthly]

    Recruiting PHASE2

  5. May 2022 — Jun 2023 [monthly]

    Recruiting PHASE2

  6. Nov 2021 — May 2022 [monthly]

    Recruiting PHASE2

  7. May 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  8. Jan 2021 — May 2021 [monthly]

    Recruiting PHASE2

  9. Aug 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  10. Apr 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  11. Feb 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  12. Dec 2019 — Feb 2020 [monthly]

    Recruiting PHASE2

  13. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  14. Oct 2019 — Nov 2019 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Bristol-Myers Squibb
  • Dan Zandberg
Data source: University of Pittsburgh

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations