deltatrials
Active Not Recruiting PHASE2 NCT04369937

HPV-16 Vaccination and Pembrolizumab Plus Cisplatin for Intermediate Risk HPV-16-associated Head and Neck Squamous Cell Carcinoma

Phase II Study Evaluating HPV-16 Vaccination (ISA101b) and Pembrolizumab Plus Cisplatin Chemoradiotherapy for Intermediate Risk HPV-16 Associated Head and Neck Squamous Cell Carcinoma (HNSCC)

Sponsor: Dan Zandberg

Updated 12 times since 2020 Last updated: Sep 10, 2025 Started: Jul 6, 2020 Primary completion: Mar 12, 2025 Completion: Jan 15, 2026

Listed as NCT04369937, this PHASE2 trial focuses on HPV-Related Squamous Cell Carcinoma and Head and Neck Squamous Cell Carcinoma and remains ongoing. Sponsored by Dan Zandberg, it has been updated 12 times since 2020, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~May 2020 – ~Aug 2020 · 3 months · monthly snapshot~Aug 2020 – ~Nov 2020 · 3 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Oct 2021 · 9 months · monthly snapshotRecruiting~Oct 2021 – ~Jun 2022 · 8 months · monthly snapshotRecruiting~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Oct 2023 · 13 months · monthly snapshotRecruiting~Oct 2023 – ~Jul 2024 · 9 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Oct 2025 · 11 months · monthly snapshotActive Not Recruiting~Oct 2025 – present · 6 months · monthly snapshot

Change History

12 versions recorded
  1. Oct 2025 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Nov 2024 — Oct 2025 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  3. Sep 2024 — Nov 2024 [monthly]

    Recruiting PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  5. Oct 2023 — Jul 2024 [monthly]

    Recruiting PHASE2

Show 7 earlier versions
  1. Sep 2022 — Oct 2023 [monthly]

    Recruiting PHASE2

  2. Jun 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  3. Oct 2021 — Jun 2022 [monthly]

    Recruiting PHASE2

  4. Jan 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  5. Nov 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  6. Aug 2020 — Nov 2020 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  7. May 2020 — Aug 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Dan Zandberg
  • ISA Pharmaceuticals
  • Merck Sharp & Dohme LLC
Data source: University of Pittsburgh

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations