deltatrials
Recruiting PHASE2 NCT04114136

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

A Phase II Clinical Trial of Anti-PD-1 mAb Therapy Alone or With Metabolic Modulators to Reverse Tumor Hypoxia and Immune Dysfunction in Solid Tumor Malignancies

Sponsor: Dan Zandberg

Conditions Esophageal Adenocarcinoma Gastric Adenocarcinoma HNSCC Hepatocellular Carcinoma Melanoma Microsatellite Instability-High Solid Malignant Tumor NSCLC Urothelial Cancer
Interventions Metformin Nivolumab or Pembrolizumab (dependent upon approved indication) Rosiglitazone
Updated 13 times since 2019 Last updated: Feb 6, 2025 Started: Sep 14, 2020 Primary completion: Apr 30, 2032 Completion: Apr 30, 2032

Listed as NCT04114136, this PHASE2 trial focuses on Esophageal Adenocarcinoma and Gastric Adenocarcinoma and remains actively recruiting participants. Sponsored by Dan Zandberg, it has been updated 13 times since 2020, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Nov 2019 – ~May 2020 · 6 months · monthly snapshot~May 2020 – ~Aug 2020 · 3 months · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Nov 2020 · 2 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Apr 2022 · 15 months · monthly snapshot~Apr 2022 – ~May 2023 · 13 months · monthly snapshot~May 2023 – ~Aug 2023 · 3 months · monthly snapshot~Aug 2023 – ~Mar 2024 · 7 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshot~Mar 2025 – present · 13 months · monthly snapshot

Change History

13 versions recorded

  1. Mar 2025 — Present [monthly]

    Recruiting PHASE2

  2. Sep 2024 — Mar 2025 [monthly]

    Recruiting PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  4. Mar 2024 — Jul 2024 [monthly]

    Recruiting PHASE2

  5. Aug 2023 — Mar 2024 [monthly]

    Recruiting PHASE2

▶ Show 8 earlier versions

  1. May 2023 — Aug 2023 [monthly]

    Recruiting PHASE2

  2. Apr 2022 — May 2023 [monthly]

    Recruiting PHASE2

  3. Jan 2021 — Apr 2022 [monthly]

    Recruiting PHASE2

  4. Nov 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  5. Sep 2020 — Nov 2020 [monthly]

    Not Yet Recruiting PHASE2

  6. Aug 2020 — Sep 2020 [monthly]

    Not Yet Recruiting PHASE2

  7. May 2020 — Aug 2020 [monthly]

    Not Yet Recruiting PHASE2

  8. Nov 2019 — May 2020 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Dan Zandberg
Data source: University of Pittsburgh

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations