A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Giredestrant Plus Palbociclib Compared With Anastrozole Plus Palbociclib for Postmenopausal Women With Estrogen Receptor-Positive and HER2-Negative Untreated Early Breast Cancer (coopERA Breast Cancer)
A Randomized, Multicenter, Open-Label, Two-Arm, Phase II, Neoadjuvant Study Evaluating the Efficacy, Safety, and Pharmacokinetics of GDC-9545 Plus Palbociclib Compared With Anastrozole Plus Palbociclib for Postmenopausal Women With Estrogen Receptor-Positive and HER2-Negative Untreated Early Breast Cancer
Sponsor: Hoffmann-La Roche
Listed as NCT04436744, this PHASE2 trial focuses on Early Breast Cancer and remains completed. Sponsored by Hoffmann-La Roche, it has been updated 21 times since 2020, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.
Status Flow
Change History
21 versions recorded-
Dec 2025 — Present [monthly]
Completed PHASE2
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Sep 2025 — Dec 2025 [monthly]
Completed PHASE2
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Sep 2024 — Sep 2025 [monthly]
Completed PHASE2
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Jul 2024 — Sep 2024 [monthly]
Completed PHASE2
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Mar 2023 — Jul 2024 [monthly]
Completed PHASE2
▶ Show 16 earlier versions
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Jul 2022 — Mar 2023 [monthly]
Completed PHASE2
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Feb 2022 — Jul 2022 [monthly]
Completed PHASE2
Status: Active Not Recruiting → Completed
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Dec 2021 — Feb 2022 [monthly]
Active Not Recruiting PHASE2
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Sep 2021 — Dec 2021 [monthly]
Active Not Recruiting PHASE2
Status: Recruiting → Active Not Recruiting
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Jun 2021 — Sep 2021 [monthly]
Recruiting PHASE2
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May 2021 — Jun 2021 [monthly]
Recruiting PHASE2
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Apr 2021 — May 2021 [monthly]
Recruiting PHASE2
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Mar 2021 — Apr 2021 [monthly]
Recruiting PHASE2
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Feb 2021 — Mar 2021 [monthly]
Recruiting PHASE2
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Jan 2021 — Feb 2021 [monthly]
Recruiting PHASE2
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Dec 2020 — Jan 2021 [monthly]
Recruiting PHASE2
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Nov 2020 — Dec 2020 [monthly]
Recruiting PHASE2
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Oct 2020 — Nov 2020 [monthly]
Recruiting PHASE2
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Sep 2020 — Oct 2020 [monthly]
Recruiting PHASE2
Status: Not Yet Recruiting → Recruiting
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Aug 2020 — Sep 2020 [monthly]
Not Yet Recruiting PHASE2
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Jul 2020 — Aug 2020 [monthly]
Not Yet Recruiting PHASE2
First recorded
Eligibility Summary
No eligibility information available.
Contact Information
- Hoffmann-La Roche
For direct contact, visit the study record on ClinicalTrials.gov .
Study Locations
Badalona, Spain , Barcelona, Spain , Burbank, United States , Dnipropetrovsk, Ukraine , Dresden, Germany , Düsseldorf, Germany , Erlangen, Germany , Gdynia, Poland , Granada, Spain , Gyeonggi-do, South Korea and 43 more locations