deltatrials
Active Not Recruiting NA INTERVENTIONAL 1-arm NCT02308085

Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer (POSITIVE)

A Study Evaluating the Pregnancy Outcomes and Safety of Interrupting Endocrine Therapy for Young Women With Endocrine Responsive Breast Cancer Who Desire Pregnancy

Sponsor: Alliance for Clinical Trials in Oncology

Conditions Early Breast Cancer
Interventions Endocrine therapy interruption
Updated 22 times since 2017 Last updated: Feb 5, 2026 Started: Dec 4, 2014 Primary completion: May 15, 2025 Completion: Dec 31, 2028
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02308085, this NA trial focuses on Early Breast Cancer and remains ongoing. Sponsored by Alliance for Clinical Trials in Oncology, it has been updated 22 times since 2014, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Oct 2017 · 9 months · monthly snapshot~Oct 2017 – ~Dec 2017 · 2 months · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Nov 2018 · 5 months · monthly snapshot~Nov 2018 – ~Jan 2019 · 2 months · monthly snapshot~Jan 2019 – ~Jun 2019 · 5 months · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshot~Sep 2019 – ~Dec 2019 · 3 months · monthly snapshot~Dec 2019 – ~Apr 2020 · 4 months · monthly snapshot~Apr 2020 – ~Sep 2020 · 5 months · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Sep 2022 · 18 months · monthly snapshot~Sep 2022 – ~Apr 2023 · 7 months · monthly snapshot~Apr 2023 – ~May 2024 · 13 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jul 2025 · 10 months · monthly snapshot~Jul 2025 – ~Sep 2025 · 2 months · monthly snapshot~Sep 2025 – ~Feb 2026 · 5 months · monthly snapshot~Feb 2026 – present · 7 months · monthly snapshot

Change History

22 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting NA

  2. Sep 2025 — Feb 2026 [monthly]

    Active Not Recruiting NA

  3. Jul 2025 — Sep 2025 [monthly]

    Active Not Recruiting NA

  4. Sep 2024 — Jul 2025 [monthly]

    Active Not Recruiting NA

  5. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting NA

▶ Show 17 earlier versions

  1. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting NA

  2. Apr 2023 — May 2024 [monthly]

    Active Not Recruiting NA

  3. Sep 2022 — Apr 2023 [monthly]

    Active Not Recruiting NA

  4. Mar 2021 — Sep 2022 [monthly]

    Active Not Recruiting NA

  5. Jan 2021 — Mar 2021 [monthly]

    Active Not Recruiting NA

  6. Sep 2020 — Jan 2021 [monthly]

    Active Not Recruiting NA

  7. Apr 2020 — Sep 2020 [monthly]

    Active Not Recruiting NA

    Status: Recruiting → Active Not Recruiting

  8. Dec 2019 — Apr 2020 [monthly]

    Recruiting NA

  9. Sep 2019 — Dec 2019 [monthly]

    Recruiting NA

  10. Jul 2019 — Sep 2019 [monthly]

    Recruiting NA

  11. Jun 2019 — Jul 2019 [monthly]

    Recruiting NA

  12. Jan 2019 — Jun 2019 [monthly]

    Recruiting NA

  13. Nov 2018 — Jan 2019 [monthly]

    Recruiting NA

  14. Jun 2018 — Nov 2018 [monthly]

    Recruiting NA

  15. Dec 2017 — Jun 2018 [monthly]

    Recruiting NA

  16. Oct 2017 — Dec 2017 [monthly]

    Recruiting NA

  17. Jan 2017 — Oct 2017 [monthly]

    Recruiting NA

    First recorded

Dec 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Alliance for Clinical Trials in Oncology
  • Breast International Group
  • Canadian Cancer Trials Group
  • ETOP IBCSG Partners Foundation
Data source: ETOP IBCSG Partners Foundation

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Albuquerque, United States , Amagasaki, Japan , Ann Arbor, United States , Athens, Greece , Atlanta, United States , Aurora, United States , Aviano, Italy , Baden, Switzerland , Baltimore, United States , Barcelona, Spain and 160 more locations