Completed PHASE3 INTERVENTIONAL 2-arm NCT00002944

Combination Chemotherapy in Treating Children With Progressive Brain Tumors

Chemotherapy for Progressive Low Grade Astrocytoma in Children Less Than Ten Years Old

Sponsor: Children's Oncology Group

Conditions Brain Tumors Central Nervous System Tumors

Interventions carboplatin lomustine procarbazine hydrochloride thioguanine vincristine sulfate

Updated 7 times since 2017 Last updated: Sep 6, 2013 Started: Apr 30, 1997 Primary completion: Feb 28, 2006 Completion: Apr 30, 2012

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Brain Tumors and Central Nervous System Tumors, this trial is completed. The trial is conducted by Children's Oncology Group and has accumulated 7 data snapshots since 1997. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

Change History

7 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Jan 2021 — Jul 2024 [monthly]

Completed PHASE3
Jun 2018 — Jan 2021 [monthly]

Completed PHASE3

▶ Show 2 earlier versions

Feb 2017 — Jun 2018 [monthly]

Completed PHASE3
Jan 2017 — Feb 2017 [monthly]

Completed PHASE3

First recorded

Apr 1997

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Children's Oncology Group
National Cancer Institute (NCI)

Data source: Children's Oncology Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Akron, United States , Albany, United States , Albuquerque, United States , Alexandria, United States , Amarillo, United States , Ann Arbor, United States , Atlanta, United States , Auckland, New Zealand , Augusta, United States , Aurora, United States and 153 more locations