deltatrials
Completed PHASE1 NCT00003625

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Newly Diagnosed Brain Stem Glioma

Vincristine, Etoposide and Cyclosporine A in Concert With Standard Dose Radiation Therapy in Diffuse Intrinsic Brain Stem Glioma - A Phase I Study of Dose Escalation of Vincristine

Sponsor: Children's Oncology Group

Conditions Brain Tumors Central Nervous System Tumors
Interventions cyclosporine etoposide radiation therapy vincristine sulfate
Updated 6 times since 2017 Last updated: Jul 25, 2014 Started: Dec 31, 1998 Primary completion: Feb 28, 2001 Completion: Apr 30, 2006

A PHASE1 clinical study on Brain Tumors and Central Nervous System Tumors, this trial is completed. The trial is conducted by Children's Oncology Group and has accumulated 6 data snapshots since 1998. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Change History

6 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE1

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE1

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  4. Jan 2021 — Jul 2024 [monthly]

    Completed PHASE1

  5. Jun 2018 — Jan 2021 [monthly]

    Completed PHASE1

▶ Show 1 earlier version

  1. Jan 2017 — Jun 2018 [monthly]

    Completed PHASE1

    First recorded

Dec 1998

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Children's Oncology Group
  • National Cancer Institute (NCI)
Data source: Children's Oncology Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Albuquerque, United States, Atlanta, United States, Baltimore, United States, Bangor, United States, Birmingham, United States, Boston, United States, Buffalo, United States, Burlington, United States, Calgary, Canada, Charleston, United States and 54 more location s