deltatrials
Active Not Recruiting PHASE1/PHASE2 INTERVENTIONAL 5-arm NCT02029443

ACP-196 (Acalabrutinib), a Novel Bruton Tyrosine Kinase (BTK) Inhibitor, for Treatment of Chronic Lymphocytic Leukemia, Richter's Syndrome or Prolymphocytic Leukemia

A Phase 1/2, Multicenter, Open-label, and Dose-escalation Study of ACP-196 in Subjects With Chronic Lymphocytic Leukemia, Richter's Syndrome or Prolymphocytic Leukemia

Sponsor: Acerta Pharma BV

Interventions Acalabrutinib
Updated 28 times since 2017 Last updated: Jan 21, 2026 Started: Jan 30, 2014 Primary completion: Jul 15, 2021 Completion: Jun 9, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1/PHASE2 trial investigates Chronic Lymphocytic Leukemia and Prolymphocytic Leukemia and is currently ongoing. Acerta Pharma BV leads this study, which shows 28 recorded versions since 2014 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshot~Jun 2018 – ~Feb 2019 · 8 months · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Jan 2021 · 22 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~May 2021 · 3 months · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Feb 2022 · 3 months · monthly snapshot~Feb 2022 – ~May 2022 · 3 months · monthly snapshot~May 2022 – ~Sep 2022 · 4 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Apr 2023 · 4 months · monthly snapshot~Apr 2023 – ~Aug 2023 · 4 months · monthly snapshot~Aug 2023 – ~Dec 2023 · 4 months · monthly snapshot~Dec 2023 – ~Mar 2024 · 3 months · monthly snapshot~Mar 2024 – ~May 2024 · 2 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Mar 2025 · 3 months · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~Sep 2025 · 5 months · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – ~Feb 2026 · 2 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

28 versions recorded
  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE1/PHASE2

  2. Dec 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  3. Sep 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  4. Apr 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  5. Mar 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE1/PHASE2

Show 23 earlier versions
  1. Dec 2024 — Mar 2025 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  2. Sep 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  3. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  4. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE1/PHASE2

    Phase: PHASE1_PHASE2PHASE1/PHASE2

  5. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  6. Mar 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  7. Dec 2023 — Mar 2024 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  8. Aug 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  9. Apr 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  10. Dec 2022 — Apr 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  11. Sep 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  12. May 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  13. Feb 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  14. Nov 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  15. Sep 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  16. May 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Unknown StatusActive Not Recruiting

  17. Feb 2021 — May 2021 [monthly]

    Unknown Status PHASE1_PHASE2

    Status: Active Not RecruitingUnknown Status

  18. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  19. Mar 2019 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Unknown StatusActive Not Recruiting

  20. Feb 2019 — Mar 2019 [monthly]

    Unknown Status PHASE1_PHASE2

    Status: Active Not RecruitingUnknown Status

  21. Jun 2018 — Feb 2019 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  22. Feb 2017 — Jun 2018 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  23. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    First recorded

Jan 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Acerta Pharma BV
Data source: Acerta Pharma BV

For direct contact, visit the study record on ClinicalTrials.gov .