deltatrials
Active Not Recruiting PHASE1 INTERVENTIONAL 2-arm NCT02157324

Acalabrutinib in Combination With ACP-319, for Treatment of Chronic Lymphocytic Leukemia

A Multicenter, Open-label, Phase 1 Pilot Study of ACP-196 in Combination With ACP-319 in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia

Sponsor: Acerta Pharma BV

Conditions Chronic Lymphocytic Leukemia
Interventions ACP-319 acalabrutinib
Updated 25 times since 2017 Last updated: Aug 12, 2025 Started: Aug 18, 2014 Primary completion: Jul 20, 2020 Completion: Apr 1, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Chronic Lymphocytic Leukemia and is currently ongoing. Acerta Pharma BV leads this study, which shows 25 recorded versions since 2014 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshot~Jun 2018 – ~Mar 2019 · 9 months · monthly snapshot~Mar 2019 – ~Jan 2021 · 22 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Apr 2021 · 59 days · monthly snapshot~Apr 2021 – ~Sep 2021 · 5 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Feb 2022 · 3 months · monthly snapshot~Feb 2022 – ~Jun 2022 · 4 months · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Apr 2023 · 4 months · monthly snapshot~Apr 2023 – ~Aug 2023 · 4 months · monthly snapshot~Aug 2023 – ~Dec 2023 · 4 months · monthly snapshot~Dec 2023 – ~Mar 2024 · 3 months · monthly snapshot~Mar 2024 – ~May 2024 · 2 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Feb 2025 · 3 months · monthly snapshot~Feb 2025 – ~Jun 2025 · 4 months · monthly snapshot~Jun 2025 – ~Sep 2025 · 3 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

25 versions recorded

  1. Sep 2025 — Present [monthly]

    Active Not Recruiting PHASE1

  2. Jun 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Feb 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Nov 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE1

▶ Show 20 earlier versions

  1. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  2. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE1

  3. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  4. Mar 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Dec 2023 — Mar 2024 [monthly]

    Active Not Recruiting PHASE1

  6. Aug 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE1

  7. Apr 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE1

  8. Dec 2022 — Apr 2023 [monthly]

    Active Not Recruiting PHASE1

  9. Sep 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE1

  10. Jun 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1

  11. Feb 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE1

  12. Nov 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE1

  13. Sep 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE1

  14. Apr 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1

    Status: Unknown Status → Active Not Recruiting

  15. Feb 2021 — Apr 2021 [monthly]

    Unknown Status PHASE1

    Status: Active Not Recruiting → Unknown Status

  16. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE1

  17. Mar 2019 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1

  18. Jun 2018 — Mar 2019 [monthly]

    Active Not Recruiting PHASE1

  19. Feb 2017 — Jun 2018 [monthly]

    Active Not Recruiting PHASE1

  20. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE1

    First recorded

Aug 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Acerta Pharma BV
Data source: Acerta Pharma BV

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations