deltatrials
Completed PHASE1 INTERVENTIONAL 4-arm NCT02296918

Acalabrutinib in Combination With Anti-CD20 and Venetoclax in Relapsed/Refractory or Untreated CLL/SLL/PLL

A Phase 1b Study of ACP-196 in Combination With Obinutuzumab for Patients With Relapsed / Refractory or Untreated CLL/SLL/PLL

Sponsor: Acerta Pharma BV

Conditions Chronic Lymphocytic Leukemia Prolymphocytic Leukemia Small Lymphocytic Lymphoma
Interventions Obinutuzumab Rituximab Venetoclax acalabrutinib
Updated 25 times since 2017 Last updated: Dec 15, 2025 Started: Dec 22, 2014 Primary completion: Aug 20, 2021 Completion: Oct 22, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Chronic Lymphocytic Leukemia and Prolymphocytic Leukemia, this trial is completed. The trial is conducted by Acerta Pharma BV and has accumulated 25 data snapshots since 2014. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Feb 2018 · 12 months · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Mar 2019 · 9 months · monthly snapshot~Mar 2019 – ~Oct 2019 · 7 months · monthly snapshot~Oct 2019 – ~Jan 2021 · 15 months · monthly snapshot~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Jan 2022 · 3 months · monthly snapshot~Jan 2022 – ~Apr 2022 · 3 months · monthly snapshot~Apr 2022 – ~Nov 2023 · 19 months · monthly snapshot~Nov 2023 – ~Feb 2024 · 3 months · monthly snapshot~Feb 2024 – ~May 2024 · 3 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Mar 2025 · 3 months · monthly snapshot~Mar 2025 – ~Jun 2025 · 3 months · monthly snapshot~Jun 2025 – ~Oct 2025 · 4 months · monthly snapshot~Oct 2025 – ~Dec 2025 · 2 months · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – present · 6 months · monthly snapshot

Change History

25 versions recorded

  1. Jan 2026 — Present [monthly]

    Completed PHASE1

  2. Dec 2025 — Jan 2026 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  3. Oct 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Jun 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Mar 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE1

▶ Show 20 earlier versions

  1. Dec 2024 — Mar 2025 [monthly]

    Active Not Recruiting PHASE1

  2. Sep 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE1

  3. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  4. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE1

  5. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  6. Feb 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE1

  7. Nov 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE1

  8. Apr 2022 — Nov 2023 [monthly]

    Active Not Recruiting PHASE1

  9. Jan 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE1

  10. Oct 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE1

  11. Sep 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE1

  12. May 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1

  13. Jan 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE1

  14. Oct 2019 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1

  15. Mar 2019 — Oct 2019 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  16. Jun 2018 — Mar 2019 [monthly]

    Recruiting PHASE1

  17. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE1

    Status: Active Not Recruiting → Recruiting

  18. Feb 2018 — Mar 2018 [monthly]

    Active Not Recruiting PHASE1

  19. Feb 2017 — Feb 2018 [monthly]

    Active Not Recruiting PHASE1

  20. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE1

    First recorded

Dec 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Acerta Pharma BV
Data source: Acerta Pharma BV

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations