deltatrials
Completed PHASE1 INTERVENTIONAL 1-arm NCT02112526

Acalabrutinib (ACP-196), a Btk Inhibitor, for Treatment of de Novo Activated B-cell (ABC) Subtype of Diffuse Large B-Cell Lymphoma

An Open-label, Phase 1b Study of ACP 196 in Subjects With Relapsed or Refractory de Novo Activated B-cell (ABC) Subtype of Diffuse Large B-Cell Lymphoma

Sponsor: Acerta Pharma BV

Conditions Activated B-cell Diffuse Large B-Cell Lymphoma (ABC DLBCL)
Interventions Acalabrutinib
Updated 27 times since 2017 Last updated: Nov 27, 2024 Started: Aug 7, 2014 Primary completion: Jun 30, 2020 Completion: Oct 4, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Activated B-cell Diffuse Large B-Cell Lymphoma (ABC DLBCL), this trial is completed. The trial is conducted by Acerta Pharma BV and has accumulated 27 data snapshots since 2014. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Feb 2018 · 12 months · monthly snapshot~Feb 2018 – ~Jun 2018 · 4 months · monthly snapshot~Jun 2018 – ~Mar 2019 · 9 months · monthly snapshot~Mar 2019 – ~Jul 2019 · 4 months · monthly snapshot~Jul 2019 – ~Aug 2020 · 13 months · monthly snapshot~Aug 2020 – ~Dec 2020 · 4 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Sep 2021 · 5 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Jan 2022 · 2 months · monthly snapshot~Jan 2022 – ~Apr 2022 · 3 months · monthly snapshot~Apr 2022 – ~Jul 2022 · 3 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Mar 2023 · 59 days · monthly snapshot~Mar 2023 – ~Jun 2023 · 3 months · monthly snapshot~Jun 2023 – ~Nov 2023 · 5 months · monthly snapshot~Nov 2023 – ~Feb 2024 · 3 months · monthly snapshot~Feb 2024 – ~May 2024 · 3 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshot~Jan 2025 – present · 19 months · monthly snapshot

Change History

27 versions recorded

  1. Jan 2025 — Present [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  2. Sep 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  4. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE1

  5. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

▶ Show 22 earlier versions

  1. Feb 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE1

  2. Nov 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE1

  3. Jun 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE1

  4. Mar 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE1

  5. Jan 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE1

  6. Dec 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE1

  7. Sep 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE1

  8. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1

  9. Apr 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE1

  10. Jan 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE1

  11. Nov 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE1

  12. Sep 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE1

  13. Apr 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1

  14. Jan 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE1

  15. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1

  16. Aug 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE1

  17. Jul 2019 — Aug 2020 [monthly]

    Active Not Recruiting PHASE1

  18. Mar 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE1

    Status: Unknown Status → Active Not Recruiting

  19. Jun 2018 — Mar 2019 [monthly]

    Unknown Status PHASE1

  20. Feb 2018 — Jun 2018 [monthly]

    Unknown Status PHASE1

    Status: Active Not Recruiting → Unknown Status

  21. Feb 2017 — Feb 2018 [monthly]

    Active Not Recruiting PHASE1

  22. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE1

    First recorded

Aug 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Acerta Pharma BV
Data source: Acerta Pharma BV

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations