deltatrials
Active Not Recruiting PHASE3 INTERVENTIONAL 2-arm NCT04529772

A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312) (ESCALADE)

Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Acalabrutinib in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Subjects ≤75 Years With Previously Untreated Non-GCB DLBCL

Sponsor: Acerta Pharma BV

Updated 40 times since 2020 Last updated: Dec 23, 2025 Started: Oct 8, 2020 Primary completion: Feb 1, 2027 Completion: Feb 1, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Diffuse Large B-Cell Lymphoma and is currently ongoing. Acerta Pharma BV leads this study, which shows 40 recorded versions since 2020 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Sep 2020 – ~Dec 2020 · 3 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~May 2021 · 2 months · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Jan 2022 · 2 months · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~May 2022 · 2 months · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~Aug 2023 · 4 months · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Apr 2024 · 2 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Jan 2025 · 3 months · monthly snapshot~Jan 2025 – ~Apr 2025 · 3 months · monthly snapshot~Apr 2025 – ~Aug 2025 · 4 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Dec 2025 · 2 months · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – present · 6 months · monthly snapshot

Change History

40 versions recorded
  1. Jan 2026 — Present [monthly]

    Active Not Recruiting PHASE3

  2. Dec 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE3

  3. Oct 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE3

Show 35 earlier versions
  1. Apr 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE3

  2. Jan 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE3

  3. Oct 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE3

  5. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  6. Apr 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  7. Feb 2024 — Apr 2024 [monthly]

    Recruiting PHASE3

  8. Jan 2024 — Feb 2024 [monthly]

    Recruiting PHASE3

  9. Dec 2023 — Jan 2024 [monthly]

    Recruiting PHASE3

  10. Nov 2023 — Dec 2023 [monthly]

    Recruiting PHASE3

  11. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE3

  12. Sep 2023 — Oct 2023 [monthly]

    Recruiting PHASE3

  13. Aug 2023 — Sep 2023 [monthly]

    Recruiting PHASE3

  14. Apr 2023 — Aug 2023 [monthly]

    Recruiting PHASE3

  15. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE3

  16. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE3

  17. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE3

  18. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE3

  19. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE3

  20. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE3

  21. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE3

  22. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE3

  23. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE3

  24. Mar 2022 — May 2022 [monthly]

    Recruiting PHASE3

  25. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE3

  26. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE3

  27. Nov 2021 — Jan 2022 [monthly]

    Recruiting PHASE3

  28. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE3

  29. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE3

  30. May 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  31. Mar 2021 — May 2021 [monthly]

    Recruiting PHASE3

  32. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE3

  33. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE3

  34. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

  35. Sep 2020 — Dec 2020 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Acerta Pharma BV
  • AstraZeneca
Data source: Acerta Pharma BV

For direct contact, visit the study record on ClinicalTrials.gov .