deltatrials
Completed PHASE1 INTERVENTIONAL 1-arm NCT02535286

Study of Immunotherapy in Combination With Ublituximab and Umbralisib in Patients With Relapsed-refractory CLL or Richter's Transformation

Phase I Study of Ublituximab and Umbralisib in Combination With Targeted Immunotherapy in Patients With Relapsed-refractory Chronic Lymphocytic Leukemia (CLL) or Richter's Transformation (RT) of CLL

Sponsor: Memorial Sloan Kettering Cancer Center

Conditions Chronic Lymphocytic Leukemia Richter Syndrome
Interventions TG-1501 Umbralisib ublituximab
Updated 37 times since 2017 Last updated: Oct 19, 2022 Started: Sep 18, 2015 Primary completion: Nov 4, 2021 Completion: Nov 4, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Chronic Lymphocytic Leukemia and Richter Syndrome, this trial is completed. The trial is conducted by Memorial Sloan Kettering Cancer Center and has accumulated 37 data snapshots since 2015. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Jun 2018 · 13 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~May 2019 · 7 months · monthly snapshot~May 2019 – ~Oct 2019 · 5 months · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Feb 2022 · 2 months · monthly snapshot~Feb 2022 – ~Jul 2022 · 5 months · monthly snapshot~Jul 2022 – ~Nov 2022 · 4 months · monthly snapshot~Nov 2022 – ~Jul 2024 · 20 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 22 months · monthly snapshot

Change History

37 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  3. Nov 2022 — Jul 2024 [monthly]

    Completed PHASE1

  4. Jul 2022 — Nov 2022 [monthly]

    Completed PHASE1

  5. Feb 2022 — Jul 2022 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed · Phase: PHASE1_PHASE2 → PHASE1

▶ Show 32 earlier versions

  1. Dec 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  2. Nov 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  3. Oct 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  4. Sep 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  5. Jun 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  6. May 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  7. Apr 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  8. Mar 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting

  9. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE1_PHASE2

  10. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1_PHASE2

  11. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1_PHASE2

  12. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE1_PHASE2

  13. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE1_PHASE2

  14. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE1_PHASE2

  15. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE1_PHASE2

  16. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE1_PHASE2

  17. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE1_PHASE2

  18. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE1_PHASE2

  19. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE1_PHASE2

  20. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE1_PHASE2

  21. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1_PHASE2

  22. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1_PHASE2

  23. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE1_PHASE2

  24. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1_PHASE2

  25. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE1_PHASE2

  26. May 2019 — Oct 2019 [monthly]

    Recruiting PHASE1_PHASE2

  27. Oct 2018 — May 2019 [monthly]

    Recruiting PHASE1_PHASE2

  28. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE1_PHASE2

  29. Jun 2018 — Sep 2018 [monthly]

    Recruiting PHASE1_PHASE2

  30. May 2017 — Jun 2018 [monthly]

    Recruiting PHASE1_PHASE2

  31. Feb 2017 — May 2017 [monthly]

    Recruiting PHASE1_PHASE2

  32. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1_PHASE2

    First recorded

Sep 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Memorial Sloan Kettering Cancer Center
  • TG Therapeutics, Inc.
Data source: TG Therapeutics, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations