deltatrials
Terminated PHASE1 INTERVENTIONAL 3-arm NCT03671590

Study of TG-1701, an Irreversible Bruton's Tyrosine Kinase Inhibitor, in Patients With B-Cell Malignancies

A Phase 1 Pharmacokinetic and Pharmacodynamic Study of TG-1701, an Irreversible Bruton's Tyrosine Kinase Inhibitor, in Patients With B-Cell Malignancies

Sponsor: TG Therapeutics, Inc.

Conditions Chronic Lymphocytic Leukemia Non Hodgkin Lymphoma
Interventions TG-1701 Ublituximab Umbralisib
Updated 57 times since 2018 Last updated: Jul 18, 2024 Started: Sep 10, 2018 Primary completion: May 21, 2024 Completion: May 21, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Strategic/Business Decision

Other terminated trials from TG Therapeutics, Inc.

More terminations from TG Therapeutics, Inc.

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A PHASE1 clinical study on Chronic Lymphocytic Leukemia and Non Hodgkin Lymphoma, this trial is terminated or withdrawn. The trial is conducted by TG Therapeutics, Inc. and has accumulated 57 data snapshots since 2018. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Oct 2018 – ~Oct 2019 · 12 months · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jul 2023 · 2 months · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

57 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated PHASE1

  2. Sep 2024 — Sep 2025 [monthly]

    Terminated PHASE1

  3. Aug 2024 — Sep 2024 [monthly]

    Terminated PHASE1

  4. Jul 2024 — Aug 2024 [monthly]

    Terminated PHASE1

    Status: Active Not Recruiting → Terminated

  5. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

▶ Show 52 earlier versions

  1. May 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE1

  2. Apr 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE1

  3. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE1

  4. Feb 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Jan 2024 — Feb 2024 [monthly]

    Active Not Recruiting PHASE1

  6. Dec 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE1

  7. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE1

  8. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE1

  9. Sep 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE1

  10. Aug 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE1

  11. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE1

  12. May 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE1

  13. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE1

  14. Mar 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE1

  15. Feb 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE1

  16. Jan 2023 — Feb 2023 [monthly]

    Active Not Recruiting PHASE1

  17. Dec 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE1

  18. Nov 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE1

  19. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  20. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE1

  21. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE1

  22. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE1

  23. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE1

  24. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE1

  25. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE1

  26. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE1

  27. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE1

  28. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE1

  29. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE1

  30. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE1

  31. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  32. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE1

  33. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE1

  34. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE1

  35. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE1

  36. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1

  37. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  38. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  39. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE1

  40. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

  41. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE1

  42. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE1

  43. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE1

  44. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE1

  45. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE1

  46. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  47. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1

  48. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1

  49. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  50. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  51. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

  52. Oct 2018 — Oct 2019 [monthly]

    Recruiting PHASE1

    First recorded

Sep 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • TG Therapeutics, Inc.
Data source: TG Therapeutics, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations