deltatrials
Terminated PHASE2 INTERVENTIONAL 3-arm NCT02656303

A Study to Evaluate the Safety and Efficacy of Ublituximab in Combination With Umbralisib for Participants Previously Enrolled in Protocol UTX-TGR-304

A Multi-Center, Open-Label, Compassionate Use Extension Study of Ublituximab (TG-1101) in Combination With Umbralisib (TGR-1202) for Patients Previously Enrolled in Protocol UTX-TGR-304

Sponsor: TG Therapeutics, Inc.

Conditions Chronic Lymphocytic Leukemia
Interventions Ublituximab Umbralisib
Updated 47 times since 2017 Last updated: May 26, 2023 Started: Jan 7, 2016 Primary completion: May 26, 2022 Completion: Jul 11, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Strategic/Business Decision

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A PHASE2 clinical study on Chronic Lymphocytic Leukemia, this trial is terminated or withdrawn. The trial is conducted by TG Therapeutics, Inc. and has accumulated 47 data snapshots since 2016. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshot~Jun 2018 – ~Oct 2018 · 4 months · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Feb 2019 · 2 months · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Aug 2019 · 5 months · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Jul 2023 · 10 months · monthly snapshot~Jul 2023 – ~Jul 2024 · 12 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

47 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Terminated PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE2

  4. Jul 2023 — Jul 2024 [monthly]

    Terminated PHASE2

  5. Sep 2022 — Jul 2023 [monthly]

    Terminated PHASE2

    Status: Active Not Recruiting → Terminated

▶ Show 42 earlier versions

  1. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  2. Jun 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE2

  3. May 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE2

  4. Apr 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE2

  5. Mar 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE2

    Status: Enrolling By Invitation → Active Not Recruiting

  6. Feb 2022 — Mar 2022 [monthly]

    Enrolling By Invitation PHASE2

  7. Jan 2022 — Feb 2022 [monthly]

    Enrolling By Invitation PHASE2

  8. Dec 2021 — Jan 2022 [monthly]

    Enrolling By Invitation PHASE2

  9. Nov 2021 — Dec 2021 [monthly]

    Enrolling By Invitation PHASE2

  10. Oct 2021 — Nov 2021 [monthly]

    Enrolling By Invitation PHASE2

  11. Sep 2021 — Oct 2021 [monthly]

    Enrolling By Invitation PHASE2

  12. Jun 2021 — Sep 2021 [monthly]

    Enrolling By Invitation PHASE2

  13. May 2021 — Jun 2021 [monthly]

    Enrolling By Invitation PHASE2

  14. Apr 2021 — May 2021 [monthly]

    Enrolling By Invitation PHASE2

  15. Mar 2021 — Apr 2021 [monthly]

    Enrolling By Invitation PHASE2

  16. Feb 2021 — Mar 2021 [monthly]

    Enrolling By Invitation PHASE2

  17. Jan 2021 — Feb 2021 [monthly]

    Enrolling By Invitation PHASE2

  18. Dec 2020 — Jan 2021 [monthly]

    Enrolling By Invitation PHASE2

  19. Nov 2020 — Dec 2020 [monthly]

    Enrolling By Invitation PHASE2

  20. Oct 2020 — Nov 2020 [monthly]

    Enrolling By Invitation PHASE2

  21. Sep 2020 — Oct 2020 [monthly]

    Enrolling By Invitation PHASE2

  22. Aug 2020 — Sep 2020 [monthly]

    Enrolling By Invitation PHASE2

  23. Jul 2020 — Aug 2020 [monthly]

    Enrolling By Invitation PHASE2

  24. Jun 2020 — Jul 2020 [monthly]

    Enrolling By Invitation PHASE2

  25. May 2020 — Jun 2020 [monthly]

    Enrolling By Invitation PHASE2

  26. Apr 2020 — May 2020 [monthly]

    Enrolling By Invitation PHASE2

  27. Mar 2020 — Apr 2020 [monthly]

    Enrolling By Invitation PHASE2

  28. Feb 2020 — Mar 2020 [monthly]

    Enrolling By Invitation PHASE2

  29. Jan 2020 — Feb 2020 [monthly]

    Enrolling By Invitation PHASE2

  30. Dec 2019 — Jan 2020 [monthly]

    Enrolling By Invitation PHASE2

  31. Nov 2019 — Dec 2019 [monthly]

    Enrolling By Invitation PHASE2

  32. Oct 2019 — Nov 2019 [monthly]

    Enrolling By Invitation PHASE2

  33. Sep 2019 — Oct 2019 [monthly]

    Enrolling By Invitation PHASE2

    Status: Recruiting → Enrolling By Invitation

  34. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  35. Mar 2019 — Aug 2019 [monthly]

    Recruiting PHASE2

  36. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE2

  37. Dec 2018 — Feb 2019 [monthly]

    Recruiting PHASE2

  38. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE2

  39. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE2

  40. Jun 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  41. Feb 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

  42. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Jan 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • TG Therapeutics, Inc.
Data source: TG Therapeutics, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Albany, United States , Ann Arbor, United States , Aurora, United States , Blacksburg, United States , Boca Raton, United States , Bridgeport, United States , Camp Hill, United States , Canton, United States , Chandler, United States , Charlotte, United States and 70 more locations