deltatrials
Recruiting PHASE2 INTERVENTIONAL 2-arm NCT02734537

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Phase II Randomized Trial of Radiotherapy With or Without Cisplatin for Surgically Resected Squamous Cell Carcinoma of the Head and Neck (SCCHN) With TP53 Sequencing

Sponsor: ECOG-ACRIN Cancer Research Group

Conditions Head and Neck Squamous Cell Carcinoma Hypopharyngeal Squamous Cell Carcinoma Laryngeal Squamous Cell Carcinoma Laryngeal Squamous Cell Carcinoma, Spindle Cell Variant Lip and Oral Cavity Squamous Cell Carcinoma Stage III Hypopharyngeal Carcinoma AJCC v8 Stage III Laryngeal Cancer AJCC v8 Stage III Lip and Oral Cavity Cancer AJCC v8 Stage III Oral Cavity Verrucous Carcinoma Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8 Stage IVA Hypopharyngeal Carcinoma AJCC v8 Stage IVA Laryngeal Cancer AJCC v8 Stage IVA Lip and Oral Cavity Cancer AJCC v8 Stage IVA Oral Cavity Verrucous Carcinoma Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8 p16INK4a Negative Oropharyngeal Squamous Cell Carcinoma
Interventions Cisplatin Intensity-Modulated Radiation Therapy Laboratory Biomarker Analysis
Updated 24 times since 2017 Last updated: Feb 27, 2026 Started: Nov 23, 2016 Primary completion: Dec 31, 2027 Completion: Dec 31, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Head and Neck Squamous Cell Carcinoma and Hypopharyngeal Squamous Cell Carcinoma, this trial is actively recruiting participants. The trial is conducted by ECOG-ACRIN Cancer Research Group and has accumulated 24 data snapshots since 2016. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Aug 2017 · 6 months · monthly snapshot~Aug 2017 – ~Dec 2017 · 4 months · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Dec 2019 · 15 months · monthly snapshot~Dec 2019 – ~Jun 2020 · 6 months · monthly snapshot~Jun 2020 – ~Jan 2021 · 7 months · monthly snapshot~Jan 2021 – ~Dec 2021 · 11 months · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Jul 2022 · 6 months · monthly snapshot~Jul 2022 – ~Apr 2023 · 9 months · monthly snapshot~Apr 2023 – ~Jul 2023 · 3 months · monthly snapshot~Jul 2023 – ~Jul 2024 · 12 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Nov 2025 · 31 days · monthly snapshot~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshot~Feb 2026 – ~Mar 2026 · 28 days · monthly snapshot~Mar 2026 – present · 4 months · monthly snapshot

Change History

24 versions recorded

  1. Mar 2026 — Present [monthly]

    Recruiting PHASE2

  2. Feb 2026 — Mar 2026 [monthly]

    Recruiting PHASE2

  3. Jan 2026 — Feb 2026 [monthly]

    Recruiting PHASE2

  4. Dec 2025 — Jan 2026 [monthly]

    Recruiting PHASE2

  5. Nov 2025 — Dec 2025 [monthly]

    Recruiting PHASE2

▶ Show 19 earlier versions

  1. Oct 2025 — Nov 2025 [monthly]

    Recruiting PHASE2

  2. Sep 2025 — Oct 2025 [monthly]

    Recruiting PHASE2

  3. Sep 2024 — Sep 2025 [monthly]

    Recruiting PHASE2

  4. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  5. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE2

  6. Jul 2023 — Jul 2024 [monthly]

    Recruiting PHASE2

  7. Apr 2023 — Jul 2023 [monthly]

    Recruiting PHASE2

  8. Jul 2022 — Apr 2023 [monthly]

    Recruiting PHASE2

  9. Jan 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  10. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE2

  11. Jan 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

  12. Jun 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  13. Dec 2019 — Jun 2020 [monthly]

    Recruiting PHASE2

  14. Sep 2018 — Dec 2019 [monthly]

    Recruiting PHASE2

  15. Jun 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

  16. Dec 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

  17. Aug 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

  18. Feb 2017 — Aug 2017 [monthly]

    Recruiting PHASE2

  19. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

Nov 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • ECOG-ACRIN Cancer Research Group
  • National Cancer Institute (NCI)
Data source: Eastern Cooperative Oncology Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aberdeen, United States , Aitkin, United States , Albert Lea, United States , Albuquerque, United States , Allentown, United States , Alton, United States , Altoona, United States , Anaconda, United States , Anchorage, United States , Ankeny, United States and 388 more locations