deltatrials
Terminated PHASE3 INTERVENTIONAL 4-arm NCT02612311

Ublituximab + TGR-1202 Compared to Obinutuzumab + Chlorambucil in Participants With Untreated and Previously Treated Chronic Lymphocytic Leukemia (UNITY-CLL)

Phase 3, Randomized Study to Assess the Efficacy and Safety of Ublituximab in Combination With TGR-1202 (Umbralisib) Compared to Obinutuzumab in Combination With Chlorambucil in Patients With Chronic Lymphocytic Leukemia (CLL)

Sponsor: TG Therapeutics, Inc.

Conditions Chronic Lymphocytic Leukemia
Interventions Chlorambucil Obinutuzumab TGR-1202 Ublituximab
Updated 55 times since 2017 Last updated: Nov 25, 2024 Started: Nov 19, 2015 Primary completion: Feb 22, 2023 Completion: Feb 22, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Strategic/Business decision

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A PHASE3 clinical study on Chronic Lymphocytic Leukemia, this trial is terminated or withdrawn. The trial is conducted by TG Therapeutics, Inc. and has accumulated 55 data snapshots since 2015. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Jul 2017 · 2 months · monthly snapshot~Jul 2017 – ~Nov 2017 · 4 months · monthly snapshot~Nov 2017 – ~Jun 2018 · 7 months · monthly snapshot~Jun 2018 – ~Jan 2019 · 7 months · monthly snapshot~Jan 2019 – ~Sep 2019 · 8 months · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jul 2023 · 2 months · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Jun 2024 · 10 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshot~Jan 2025 – ~Sep 2025 · 8 months · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

55 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated PHASE3

  2. Jan 2025 — Sep 2025 [monthly]

    Terminated PHASE3

  3. Sep 2024 — Jan 2025 [monthly]

    Terminated PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE3

  5. Jun 2024 — Jul 2024 [monthly]

    Terminated PHASE3

    Status: Completed → Terminated

▶ Show 50 earlier versions

  1. Aug 2023 — Jun 2024 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  2. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE3

  3. May 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE3

  4. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE3

  5. Mar 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE3

  6. Feb 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE3

  7. Jan 2023 — Feb 2023 [monthly]

    Active Not Recruiting PHASE3

  8. Dec 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE3

  9. Nov 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE3

  10. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE3

  11. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  12. Jun 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE3

  13. May 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE3

  14. Apr 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE3

  15. Mar 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE3

  16. Feb 2022 — Mar 2022 [monthly]

    Active Not Recruiting PHASE3

  17. Jan 2022 — Feb 2022 [monthly]

    Active Not Recruiting PHASE3

  18. Dec 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE3

  19. Nov 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE3

  20. Oct 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE3

  21. Sep 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE3

  22. Jun 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE3

  23. May 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE3

  24. Apr 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE3

  25. Mar 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE3

  26. Feb 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE3

  27. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE3

  28. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  29. Nov 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE3

  30. Oct 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE3

  31. Sep 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE3

  32. Aug 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE3

  33. Jul 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE3

  34. Jun 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE3

  35. May 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE3

  36. Apr 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE3

  37. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE3

  38. Feb 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE3

  39. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE3

  40. Dec 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE3

  41. Nov 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE3

  42. Oct 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE3

  43. Sep 2019 — Oct 2019 [monthly]

    Active Not Recruiting PHASE3

  44. Jan 2019 — Sep 2019 [monthly]

    Active Not Recruiting PHASE3

  45. Jun 2018 — Jan 2019 [monthly]

    Active Not Recruiting PHASE3

  46. Nov 2017 — Jun 2018 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  47. Jul 2017 — Nov 2017 [monthly]

    Recruiting PHASE3

  48. May 2017 — Jul 2017 [monthly]

    Recruiting PHASE3

  49. Feb 2017 — May 2017 [monthly]

    Recruiting PHASE3

  50. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE3

    First recorded

Nov 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • TG Therapeutics, Inc.
Data source: TG Therapeutics, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Albany, United States , Ames, United States , Ann Arbor, United States , Ashkelon, Israel , Aurora, United States , Austin, United States , Baltimore, United States , Barcelona, Spain , Bedford, United States , Beersheba, Israel and 135 more locations