deltatrials
Completed PHASE3 INTERVENTIONAL 1-arm NCT04008706

Acalabrutinib Safety Study in Untreated and Relapsed or Refractory Chronic Lymphocytic Leukemia Patients (ASSURE)

A Phase 3b, Multicenter, Open-Label, Single-Arm Study of Acalabrutinib (ACP-196) in Subjects With Chronic Lymphocytic Leukemia.

Sponsor: AstraZeneca

Interventions Acalabrutinib
Updated 48 times since 2019 Last updated: Nov 28, 2025 Started: Sep 17, 2019 Primary completion: Nov 4, 2025 Completion: Nov 4, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Chronic Lymphocytic Leukemia, this trial is completed. The trial is conducted by AstraZeneca and has accumulated 48 data snapshots since 2019. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Aug 2019 – ~Jan 2020 · 5 months · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Nov 2020 · 2 months · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Jan 2022 · 3 months · monthly snapshot~Jan 2022 – ~Apr 2022 · 3 months · monthly snapshot~Apr 2022 – ~Jun 2022 · 2 months · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Jan 2023 · 2 months · monthly snapshot~Jan 2023 – ~Mar 2023 · 59 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Aug 2023 · 3 months · monthly snapshot~Aug 2023 – ~Nov 2023 · 3 months · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Feb 2024 · 2 months · monthly snapshot~Feb 2024 – ~May 2024 · 3 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Feb 2025 · 3 months · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~Jun 2025 · 2 months · monthly snapshot~Jun 2025 – ~Sep 2025 · 3 months · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Nov 2025 · 31 days · monthly snapshot~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – present · 7 months · monthly snapshot

Change History

48 versions recorded
  1. Jan 2026 — Present [monthly]

    Completed PHASE3

    Status: Active Not RecruitingCompleted

  2. Dec 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE3

  3. Nov 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Oct 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE3

Show 43 earlier versions
  1. Jun 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE3

  2. Apr 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE3

  3. Mar 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Nov 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE3

  6. Oct 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE3

  7. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE3

  8. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  9. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE3

  10. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

  11. Feb 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE3

  12. Dec 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE3

  13. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE3

  14. Aug 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE3

  15. May 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE3

  16. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE3

  17. Mar 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE3

  18. Jan 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE3

  19. Nov 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE3

  20. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE3

  21. Jun 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  22. Apr 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE3

  23. Jan 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  24. Oct 2021 — Jan 2022 [monthly]

    Recruiting PHASE3

  25. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE3

  26. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  27. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE3

  28. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE3

  29. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE3

  30. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE3

  31. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE3

  32. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  33. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE3

  34. Sep 2020 — Nov 2020 [monthly]

    Recruiting PHASE3

  35. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE3

  36. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE3

  37. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE3

  38. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE3

  39. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE3

  40. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE3

  41. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE3

  42. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

  43. Aug 2019 — Jan 2020 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • AstraZeneca
  • Parexel
Data source: AstraZeneca

For direct contact, visit the study record on ClinicalTrials.gov .