Recruiting OBSERVATIONAL NCT05848271

Natural History Study of Patients with HPDL Mutations

A Patient Registry and Natural History Study of Patients with Biallelic HPDL Mutations

Sponsor: Heinrich-Heine University, Duesseldorf

Conditions Genetic Disease Hereditary Spastic Paraplegia Mitochondrial Encephalomyopathies Mutation Neonatal Encephalopathy Spastic Paraplegia White Matter Disease

Interventions Dry blood spots sampling Patient Registry

Updated 4 times since 2023 Last updated: Mar 25, 2025 Started: May 18, 2023 Primary completion: Dec 31, 2026 Completion: Dec 31, 2027

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT05848271, this observational or N/A phase trial focuses on Genetic Disease and Hereditary Spastic Paraplegia and remains actively recruiting participants. Sponsored by Heinrich-Heine University, Duesseldorf, it has been updated 4 times since 2023, reflecting limited change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

Change History

4 versions recorded

Apr 2025 — Present [monthly]

Recruiting
Sep 2024 — Apr 2025 [monthly]

Recruiting
Jul 2024 — Sep 2024 [monthly]

Recruiting
Jun 2023 — Jul 2024 [monthly]

Recruiting

First recorded

May 2023

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Heinrich-Heine University, Duesseldorf
New York University
University of California, San Diego
Universität Tübingen

Data source: University of California, San Diego

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• San Diego, United States